Adipotide
Adipotide (FTPP / Prohibitin-TP01)
Also called FTPP, prohibitin-targeting peptide, adipotide
Targeting the blood supply of fat tissue
Adipotide takes a completely different route to fat loss: instead of touching appetite, it targets the blood vessels feeding fat tissue and kills them, so the fat starves. It worked dramatically in monkeys. It also damaged their kidneys, and it has never been through a completed human trial.
An experimental peptide that takes a radically different approach to fat loss — instead of suppressing appetite, it targets the blood vessels that feed white fat tissue, triggering their controlled die-off so fat cells lose their supply. Striking in primate studies, but it never advanced in humans due to kidney-toxicity concerns, so it remains a research-only compound.
- Half-life
- Short, in the range of hours
- Route
- Injection under the skin
- Typical dose
- No established human dose. Anything quoted is extrapolated from animals
- Availability
- Research-only
Early research, mostly in the lab so far
What people use Adipotide for
Reported uses, roughly in order of how often they are the reason someone goes looking. Whether it works for any of them is a separate question, answered under each one.
- Fat loss
- The only reason anyone looks it up. In the primate work it produced fast, substantial fat loss, notably without the appetite suppression that defines every other drug in this space.
Mechanism of Action
How Adipotide works
Adipotide is a targeting peptide fused to a pro-apoptotic sequence:
- Homing to fat vasculature — the targeting portion binds prohibitin and ANXA2 markers on the blood vessels that specifically supply white adipose tissue.
- Triggered vessel apoptosis — the attached pro-apoptotic peptide then induces programmed death of those vessels, cutting off the fat's blood supply.
- Fat-cell resorption — deprived of supply, fat cells shrink and are resorbed, producing weight loss independent of appetite signaling.
- Known toxicity limit — primate studies showed rapid fat loss but also dose-dependent kidney effects, which halted human development. This is a research compound, not a therapeutic.
Adipotide dosage calculator
Enter what is in your vial, how much water you added, and the dose you are using. It works out where to pull the plunger to.
How much is in the vial?
Printed on the label, in milligrams
How much water did you add?
Bacteriostatic water, in millilitres
What dose are you taking?
The dose you already intend to use
Which syringe?
Barrel size, printed on the wrapper
Draw to
10 units
on a 0.5 mL insulin syringe (0.1 mL)
- Strength once mixed
- 5 mg/mL
- Doses in the vial
- 20
10 mg in 2 mL makes 5 mg/mL. A 500 mcg dose is 0.1 mL of that, which is 10 units.
This is arithmetic, not advice. It converts a dose you already have into a mark on a syringe. It does not tell you what dose to take, and Adipotide is not prescribed by us. Dosing belongs with a qualified clinician.
Adipotide side effects: what people reported
This is the one where the side effects are the story rather than a footnote. The kidney signal in the monkey studies is why the compound stalled.
The one that matters
- Kidney damage. It showed up in the monkey work at doses that produced the weight loss people quote, and it is dose-related
Also reported
- Dehydration
- Changes in urination
- Injection-site reactions
Source: Primate studies and a small Phase 1 in men with obesity and prostate cancer. This is a summary of published findings, not a complete safety profile and not medical advice. Adipotide should only be considered with a qualified clinician who knows your history.
Your Genetics & Adipotide
The genes involved in how Adipotide works
Adipotide works through the receptors these genes build, and the genes vary from person to person. Researchers have linked some of that variation to differences in how people respond. A DNA report tells you which versions you carry.
FTO · ••
The FTO risk allele raises baseline fat-mass and appetite drive. It frames how much white adipose tissue is present for an anti-vascular agent like Adipotide to act on.
ADRB3 · ••
The Trp64Arg variant affects fat metabolism and lipolysis in adipose tissue, shaping the metabolic backdrop against which fat loss occurs.
PPARG · ••
The Pro12Ala variant influences how readily fat cells form and store lipid, relevant to how adipose tissue responds to a vascular-targeting agent.
LEPR · ••
The Gln223Arg variant affects leptin signaling and fat regulation, part of the broader metabolic context that determines net body-composition change.
The dots after each gene are where your own result goes. Your report fills them in with the two letters you carry at that position.
Which variants do you carry?
Upload your DNA data, or get tested through our partner, to find out.
Sourcing & access
Where to buy Adipotide
Adipotide is sold as a research compound, not a licensed medicine, so quality and legal status vary widely by country and vendor. If you're sourcing it, treat independent purity testing as non-negotiable.
- Insist on a recent third-party Certificate of Analysis (COA) for the exact batch — labs like Janoshik verify purity and identity.
- Check the legal status where you live before ordering — it differs from country to country.
- Reconstitute correctly with bacteriostatic water and start at a conservative dose.
Adipotide
Targeting the blood supply of fat tissue
$63.95at Swiss Chems
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Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Worth knowing before you consider Adipotide
Interactions and situations where there is a specific reason to be careful. Where the honest answer is that nobody has studied something, it says so and says what that leaves open.
- The kidney problem is the headline, not a footnote
- Every impressive number quoted for this compound comes from the same studies that found the kidney signal. They are not separable, and there is no human dose known to avoid it.
- No completed human trial
- There is no schedule, no established dose and no safety window in people. Anyone quoting a protocol is guessing from monkeys.
Last updated
Frequently Asked Questions
How is Adipotide different from GLP-1 drugs?
GLP-1 drugs like semaglutide suppress appetite. Adipotide works through a completely different mechanism — it targets and destroys the blood vessels feeding white fat tissue, so fat cells lose their supply and shrink. It doesn't touch hunger signaling at all.
Is Adipotide safe to use?
Adipotide never advanced past animal research because primate studies showed dose-dependent kidney toxicity. It is strictly a research compound with no human safety data establishing a safe dose — this is important context before considering it at all.
Does genetics affect Adipotide response?
Metabolic and adipose genetics (FTO, ADRB3, PPARG, LEPR) frame the fat-tissue context any fat-loss agent acts on. A genetic peptide report profiles these, though with Adipotide the dominant consideration remains its unresolved safety profile.
Your next move
Two ways forward with Adipotide.
Not sure it's for you?
How does Adipotide relate to your genes?
Your report scores Adipotide against your receptor, pharmacogene and pathway variants and shows the genetic markers relevant to it, with commonly cited dosing information to review with a clinician.
Analyze my DNA — $99Already decided?
Get Adipotide from Swiss Chems.
A US research-chemical supplier with third-party Certificates of Analysis. Sold for research use only — check your local laws before ordering.
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