Adipotide
Adipotide (FTPP / Prohibitin-TP01)
Targeting the blood supply of fat tissue
An experimental peptide that takes a radically different approach to fat loss — instead of suppressing appetite, it targets the blood vessels that feed white fat tissue, triggering their controlled die-off so fat cells lose their supply. Striking in primate studies, but it never advanced in humans due to kidney-toxicity concerns, so it remains a research-only compound.
- Route
- Subcutaneous injection
- Typical dose
- Research-only (no established human dose)
- Availability
- Research-only
Key Benefits
Appetite-independent mechanism (targets fat blood supply)
Rapid fat loss demonstrated in primate studies
Novel anti-angiogenic approach to obesity research
Does not rely on GLP-1 or metabolic signaling
Mechanism of Action
How Adipotide works
Adipotide is a targeting peptide fused to a pro-apoptotic sequence:
- Homing to fat vasculature — the targeting portion binds prohibitin and ANXA2 markers on the blood vessels that specifically supply white adipose tissue.
- Triggered vessel apoptosis — the attached pro-apoptotic peptide then induces programmed death of those vessels, cutting off the fat's blood supply.
- Fat-cell resorption — deprived of supply, fat cells shrink and are resorbed, producing weight loss independent of appetite signaling.
- Known toxicity limit — primate studies showed rapid fat loss but also dose-dependent kidney effects, which halted human development. This is a research compound, not a therapeutic.
Your Genetics & Adipotide
Genetic variants that affect your response
These SNPs determine how effectively Adipotide works for you specifically. A genetic peptide report identifies your variants before you start.
The FTO risk allele raises baseline fat-mass and appetite drive. It frames how much white adipose tissue is present for an anti-vascular agent like Adipotide to act on.
The Trp64Arg variant affects fat metabolism and lipolysis in adipose tissue, shaping the metabolic backdrop against which fat loss occurs.
The Pro12Ala variant influences how readily fat cells form and store lipid, relevant to how adipose tissue responds to a vascular-targeting agent.
The Gln223Arg variant affects leptin signaling and fat regulation, part of the broader metabolic context that determines net body-composition change.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
10+
Published studies
Pathway-based inference and early research. Use with appropriate caution
Sourcing & access
Where to buy Adipotide
Adipotide is sold as a research compound, not a licensed medicine, so quality and legal status vary widely by country and vendor. If you're sourcing it, treat independent purity testing as non-negotiable.
- Insist on a recent third-party Certificate of Analysis (COA) for the exact batch — labs like Janoshik verify purity and identity.
- Check the legal status where you live before ordering — it differs from country to country.
- Reconstitute correctly with bacteriostatic water and start at a conservative dose.
Swiss Chems is a US research-chemical supplier that publishes third-party Certificates of Analysis. Sold for research use only — check your local laws.
Before you buy: see whether your DNA actually responds to Adipotide, and at what dose. Analyze my DNA — $99 →
Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you), and providers we partner with are listed first. Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Frequently Asked Questions
How is Adipotide different from GLP-1 drugs?
GLP-1 drugs like semaglutide suppress appetite. Adipotide works through a completely different mechanism — it targets and destroys the blood vessels feeding white fat tissue, so fat cells lose their supply and shrink. It doesn't touch hunger signaling at all.
Is Adipotide safe to use?
Adipotide never advanced past animal research because primate studies showed dose-dependent kidney toxicity. It is strictly a research compound with no human safety data establishing a safe dose — this is important context before considering it at all.
Does genetics affect Adipotide response?
Metabolic and adipose genetics (FTO, ADRB3, PPARG, LEPR) frame the fat-tissue context any fat-loss agent acts on. A genetic peptide report profiles these, though with Adipotide the dominant consideration remains its unresolved safety profile.
Learn More About Adipotide
Your next move
Two ways forward with Adipotide.
Not sure it's for you?
Will Adipotide work for your genes — and at what dose?
Your report scores Adipotide against your receptor, CYP and pathway variants — likely responder, non-responder, and a sensible starting dose — in minutes.
Analyze my DNA — $99Already decided?
Get Adipotide from Swiss Chems.
A US research-chemical supplier with third-party Certificates of Analysis. Sold for research use only — check your local laws before ordering.
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