The Library — A Field Guide
An evolving reference on peptides, genetics, and the biology behind both.
Essays in print
33
Dossiers
6
Last dispatch
Jun 3
Editor’s Pick · Guides
Which peptides work best for anxiety? Selank and Semax target the same problem with opposite tools. Your COMT gene determines which one helps and which backfires.
Departments
The Field Guide is organised in six standing departments. Begin where you are most curious.
Each peptide gets its own file. What it does, what the research really shows, who responds, who does not.
Why two people on the same dose of the same compound get opposite results, written in your DNA.
Mechanisms, in plain language. Receptors, pathways, half-lives, and what it all means for your protocol.
What works together, what cancels itself out, and the protocols people are actually running.
Doses, cycles, interactions, contraindications. The unflashy work that keeps the rest of it working.
Tests, services, peptides, head to head. Sorted by what actually matters.
The Archive
33 essays. Search, filter, sort, or switch to the index for a compact reference view.
Which peptides work best for anxiety? Selank and Semax target the same problem with opposite tools. Your COMT gene determines which one helps and which backfires.
Is the Wolverine Stack still the best peptide combination in 2026? Nine things changed since your last guide: FDA status, TB-500 prodrug finding, and new dose data.
Which peptides work best for sleep in 2026? DSIP, Epithalon, and ipamorelin each target different sleep problems. Your PER3 gene predicts which one you actually need.
First peptide therapy appointment? Most clinics skip labs, legal checks, and the genetic step that changes everything. Here is the 7-point checklist to run before you book.
AOD-9604 ran more human trials than most research peptides and still failed its pivotal test. Here is what the data shows and whether your genes predict your response.
Are peptides legal in the US? BPC-157 was banned in 2023, partially reversed in 2026, and is still not legal to compound. Here is exactly where every major peptide stands right now.
Your mitochondria produce MOTS-c as a metabolic hormone. Levels fall with age and collapse in diabetes. One K14Q genetic variant changes your entire response profile.
If you carry the CYP3A4*22 variant, standard drug doses can build to 150-170% of intended levels. Here is what that means for your peptide stack.
KPV and LL-37 both fight skin inflammation without thinning your skin. But they target opposite biology, and a 2024 JCI study found the wrong choice can accelerate heart disease.
Peptide cycling rules differ completely by class. Here is what the research shows about receptor desensitization, and why your genetics determines your reset window.
Epithalon broke the Hayflick limit in cultured human cells and cut cardiovascular mortality by 50% across a 12-year trial. Here is what 30 years of Russian data actually shows.
A 27,885-person study found the gene that predicts who loses weight fast on semaglutide and who barely moves. Your DNA already has the answer.
Selank matched medazepam in trials: 40% of patients hit sub-clinical anxiety in 3 days, with no withdrawal. Your BDNF and GABRA2 genes predict if you are a fast responder.
BPC-157 cut soft-tissue recovery time by up to 50% across 35+ preclinical studies. But around 1 in 5 users report no benefit. Your collagen and NOS3 genes explain why.
Ipamorelin fires a clean GH pulse that peaks at 40 minutes. CJC-1295 keeps GH elevated for six days per injection. Your GHSR and GHR genes determine which one fits your biology.
BPC-157 clears your blood in 15 minutes. TB-500 persists in tissue for days. Your CYP enzyme status and protease genetics decide how these half-lives translate to your protocol.
Picking a peptide based on your goal is the wrong starting point. Your COMT, BDNF, SOD2, and GLP1R variants determine whether a protocol works before you pick the peptide.
Your 23andMe raw file is a survey of 650,000 known variants. Here is which peptide-response SNPs it reliably genotypes, what gaps exist across chip versions, and why the data is more useful than most realize.
GHK-Cu searches have surged over 500% in the past year. Here's what this copper peptide actually does, what it doesn't, and why your genetics determine whether it's worth trying.
SelfDecode offers a peptide response report as part of their subscription platform. We break down what you get, what you don't, and how it compares to a dedicated genetic peptide test.
How much BPC-157 should you take? Find your dose by body weight. Daily vs weekly protocols, mcg per kg, oral vs injection, and why your liver enzymes change the math.
Peptide stacking searches are up 800% this year. Everyone wants to stack — but most guides ignore the genetic factors that determine whether a combination will work for you or waste your money.
Two companies now offer DNA-to-peptide matching. Here's an honest comparison of PlexusDx and PeptidesDNA — what each test covers, how they differ, and which one fits your needs.
Semaglutide dominates the headlines, but it's not the only peptide that moves the scale. Here are the top 5 peptides for weight loss — ranked by evidence — and why your GLP1R and PPARG gene variants determine which one actually works for you.
GHK-Cu, BPC-157, collagen peptides, Epithalon, Matrixyl — the skincare peptide market is exploding. Here's what actually works, what's marketing, and why your COL1A1 and SOD2 genes determine which peptide delivers results for your skin.
BPC-157, TB-500, GHK-Cu, KPV, Thymosin Alpha-1 — healing peptides cover everything from torn tendons to gut lining repair. Here's what the evidence actually supports, and how your NOS3, MMP3, and COL1A1 gene variants predict which one works best for your biology.
BPC-157 is the most-researched healing peptide in the biohacking world. Here's exactly how it works — from nitric oxide signaling to tendon repair — and why your genetics determine how well it works for you.
The most popular peptide combination in biohacking. Here's how the Wolverine Stack works, who it's best for, and what your MMP3 and FN1 gene variants mean for your response.
Everything you need to know before trying peptides — what they are, how they work, which ones are most popular, and the 5 genetic factors that affect which peptide to choose first.
GHK-Cu is the most scientifically validated anti-aging peptide in existence — 50 years of research, 4,048 genes modulated, and a direct SIRT1 binding mechanism discovered in 2025. Here's how it works and why your TGFB1 and COL1A1 variants determine your response.
10-17% of semaglutide users are non-responders. New genetic research — including a 27,885-person GWAS from 23andMe — reveals why. Your GLP1R, TCF7L2, and ARRB1 variants determine whether you'll lose 15% of your body weight or barely notice a difference.
Combining peptides can produce synergistic effects — or expensive futility. Here's the receptor rule, the CYP competition reality, the most popular stacks, and the 8 mistakes that waste your money.
Your liver's CYP450 enzymes process ~75% of all drugs — but most peptides aren't among them. Here's what CYP enzymes actually do, why your metabolizer status matters for drug interactions, and how the 7 key CYP enzymes affect your peptide protocol.
Showing 33 of 33 articles.
The Colophon
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