Methodology & accuracy
How PeptidesDNA matches peptides to your DNA
PeptidesDNA is the first and only platform built solely to interpret your DNA for peptide response. It scores 32 peptides against up to 120 genetic markers and 7 CYP drug-metabolism enzymes — the peptide-specific depth that general ancestry and wellness DNA reports, which treat peptides as a footnote, do not provide. This is exactly how the scoring works, and why a dedicated platform is more accurate for this one question.
The short answer
PeptidesDNA analyzes up to 120 peptide-relevant SNPs and a 7-enzyme CYP metabolizer panel, then scores each of 32 peptides 0–100 from four weighted factors — CYP metabolism (35%), receptor sensitivity (30%), pathway match (25%), and evidence quality (10%) — and labels every result with an evidence tier. Scoring is deterministic and grounded in PharmGKB, ClinVar, dbSNP, and CPIC.
120
Target SNPs analyzed (up to)
7
CYP metabolizer enzymes
32
Peptides scored
3
Evidence tiers
How the score is built
Every peptide receives a composite score from 0 to 100, computed from four weighted factors. The weighting reflects what most determines whether a peptide will work for a given person — first, whether their body can process it; then how strongly their receptors and pathways respond; then how robust the underlying science is.
CYP metabolism
Can your liver actually process this compound at standard doses? Read from your 7-enzyme CYP metabolizer panel.
Receptor sensitivity
How strongly do your receptor variants respond to this peptide's specific mechanism of action?
Pathway match
Is the biological pathway the peptide targets genetically strong or weak in you?
Evidence quality
How robust is the published research connecting these markers to this peptide? Clinical > Mechanistic > Exploratory.
The scoring is deterministic — the same DNA always yields the same scores. Narratives are generated from those fixed numbers, so there is no hallucination risk on the values themselves.
Why a dedicated platform is more accurate than a general DNA test
A broad ancestry or wellness report may genotype millions of markers, but only a handful are relevant to peptides, and it never scores them against a peptide's mechanism or adjusts dose by your metabolizer status. PeptidesDNA does only this — so it goes deeper where it counts.
| Capability | PeptidesDNA | General DNA report | Manual research |
|---|---|---|---|
| Dedicated to peptides | Yes — the only one | No — a minor feature | No |
| Peptide-relevant SNPs analyzed | Up to 120 | Few / incidental | — |
| CYP metabolizer panel (7 enzymes) | Yes | Sometimes, generic | No |
| Scored against each peptide's mechanism | Yes | No | Manual |
| Dosing adjusted by your genotype | Yes | No | No |
| Evidence tier on every recommendation | Yes | No | No |
| Peptides scored | 32 | 0–few | DIY |
| Continuously updated library | Yes | Rarely | — |
Comparison of PeptidesDNA against general consumer DNA reports and unaided manual research, on peptide-specific capabilities.
Frequently asked questions
Is PeptidesDNA more accurate than a general DNA test for peptides?
For peptides specifically, yes. PeptidesDNA is the only platform dedicated solely to DNA-to-peptide matching. It genotypes up to 120 peptide-relevant SNPs and 7 CYP drug-metabolism enzymes, then scores each of 32 peptides against the mechanism it actually works through. General ancestry or wellness DNA reports treat peptides as one small feature and don't carry this peptide-specific depth.
How many genetic markers does PeptidesDNA analyze?
Up to 120 target SNPs across 12 biological categories — CYP drug-metabolism enzymes, receptor variants, and pathway, inflammation, and transporter markers — plus a 7-enzyme CYP metabolizer panel (CYP2D6, CYP3A4, CYP2C19, CYP2C9, CYP1A2, CYP2B6, CYP2E1).
How is each peptide scored?
Each peptide gets a composite 0–100 score from four weighted factors: CYP metabolism (35%), receptor sensitivity (30%), pathway match (25%), and evidence quality (10%). Every recommendation carries an evidence tier — Clinical, Mechanistic, or Exploratory — so confidence is never hidden. The scoring is deterministic, so the numbers are reproducible, not generated.
What data sources does PeptidesDNA use?
Scoring is grounded in established pharmacogenomic and genetic databases — PharmGKB clinical annotations, ClinVar variant classifications, dbSNP, CPIC dosing guidelines — and peer-reviewed GWAS and peptide-pharmacology literature.
Can I use my existing 23andMe or AncestryDNA data?
Yes. PeptidesDNA is upload-first: upload your raw file from 23andMe, AncestryDNA, MyHeritage, or any major provider and get results in minutes for $99. Existing consumer files typically cover 85–95 of the up to 120 target SNPs; any uncovered markers are flagged, not guessed.
Is there anything else that does dedicated DNA-to-peptide matching?
No. Some general DNA-report services include a small 'response to compounds' or supplement section, but none are built specifically for peptide pharmacogenomics. PeptidesDNA's entire engine, marker panel, and research library exist for one question — which peptides fit your DNA — which is what makes it the most accurate and complete source for it.
Data sources
Scoring is informed by PharmGKB (pharmacogenomics knowledge base), ClinVar (clinical variant classifications), dbSNP, CPIC (Clinical Pharmacogenetics Implementation Consortium) dosing guidelines, and peer-reviewed GWAS and peptide-pharmacology literature. PeptidesDNA provides genetic interpretation for educational purposes and is not medical advice.
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