AOD-9604
Advanced Obesity Drug 9604 (hGH Fragment 177-191)
The fat metabolism peptide
A modified 16-amino-acid fragment of human growth hormone (amino acids 177-191) with a tyrosine substitution. AOD-9604 retains the fat-metabolizing activity of full-length GH without stimulating IGF-1, meaning it promotes lipolysis and inhibits lipogenesis without the growth, insulin resistance, or proliferative risks of HGH.
Key Benefits
Enhanced fat metabolism without IGF-1 elevation
Inhibition of new fat storage (lipogenesis)
Weight management without muscle-wasting effects
Potential cartilage repair and joint support
Mechanism of Action
How AOD-9604 works
AOD-9604 targets fat metabolism through growth-hormone-derived pathways while avoiding systemic growth effects:
- Beta-3 adrenergic receptor activation — stimulates lipolysis (fat breakdown) in adipose tissue by activating the same receptor pathway as the fat-burning region of natural growth hormone
- Lipogenesis inhibition — blocks the conversion of non-fatty food substrates into stored body fat, reducing new fat accumulation independent of caloric intake
- No IGF-1 stimulation — unlike full-length HGH, AOD-9604 does not raise IGF-1 levels, eliminating risks of insulin resistance, acromegaly-like effects, and proliferative concerns
- Cartilage repair signaling — emerging evidence suggests AOD-9604 stimulates proteoglycan synthesis in chondrocytes, which is why it received Australian TGA regulatory consideration for osteoarthritis
Your Genetics & AOD-9604
Genetic variants that affect your response
These SNPs determine how effectively AOD-9604 works for you specifically. A genetic peptide report identifies your variants before you start.
The GHR d3 (exon 3 deletion) polymorphism affects GH receptor sensitivity. d3 carriers have enhanced GH signaling — since AOD-9604 is a GH fragment, receptor sensitivity variants may influence fat-metabolizing response.
The Pro12Ala variant affects adipocyte differentiation and insulin sensitivity. Ala carriers tend to have smaller fat cells and better insulin sensitivity — AOD-9604's lipogenesis inhibition may be more impactful in Pro/Pro individuals with larger, more insulin-resistant adipocytes.
The Trp64Arg variant in the beta-3 adrenergic receptor reduces lipolytic response. Since AOD-9604 acts partly through beta-3 receptor pathways, carriers of the Arg64 variant may have a blunted fat-burning response.
The strongest common genetic risk factor for obesity. AA carriers have higher baseline fat mass and altered energy metabolism — AOD-9604's targeted fat metabolism effect addresses the metabolic component, though FTO also affects appetite regulation.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
15+
Published studies
Animal studies and in vitro data with promising but limited clinical validation
Sourcing & access
Where to buy AOD-9604
AOD-9604 is sold as a research compound, not a licensed medicine, so quality and legal status vary widely by country and vendor. If you're sourcing it, treat independent purity testing as non-negotiable.
- Insist on a recent third-party Certificate of Analysis (COA) for the exact batch — labs like Janoshik verify purity and identity.
- Check the legal status where you live before ordering — it differs from country to country.
- Reconstitute correctly with bacteriostatic water and start at a conservative dose.
Before you buy: see whether your DNA actually responds to AOD-9604, and at what dose. Analyze my DNA — $99 →
Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Common Stacks
AOD-9604 is commonly combined with:
CJC-1295
Fat Loss + GH StackModerate EvidenceCJC-1295 (Modified GRF 1-29)
A 29-amino-acid growth hormone releasing hormone (GHRH) analog with enhanced stability. CJC-1295 extends the duration of natural GH pulses without disrupting pulsatile release patterns, providing sustained elevation of growth hormone and IGF-1 for recovery, body composition, and anti-aging.
4
Gene variants
30+
Studies
BPC-157
Metabolic + Joint StackModerate EvidenceBody Protection Compound 157
A 15-amino-acid peptide derived from human gastric juice. The most-researched peptide for tissue repair, gut healing, and injury recovery. Works through nitric oxide signaling, angiogenesis, and collagen stimulation.
4
Gene variants
100+
Studies
MOTS-c
Metabolic Optimization StackEmerging EvidenceMitochondrial Open Reading Frame of the 12S rRNA Type-c
A 16-amino-acid peptide encoded by the mitochondrial genome — one of only a handful of known mitochondrial-derived peptides (MDPs). MOTS-c acts as a retrograde signal from mitochondria to the nucleus, activating AMPK and regulating metabolic homeostasis. It functions as an exercise mimetic, improving insulin sensitivity, fat oxidation, and cellular stress resilience.
3
Gene variants
25+
Studies
Frequently Asked Questions
What is AOD-9604 used for?
AOD-9604 is used for fat loss and weight management. As a modified fragment of human growth hormone, it stimulates fat breakdown (lipolysis) and blocks new fat storage (lipogenesis) without raising IGF-1. This gives it the fat-metabolizing benefit of HGH without the growth, insulin, or proliferative risks.
Does genetics affect AOD-9604 response?
Yes. ADRB3 variants affect the beta-3 adrenergic receptor AOD-9604 acts through — the Trp64Arg variant can blunt lipolytic response. GHR d3 deletion affects growth hormone receptor sensitivity. PPARG and FTO variants influence baseline fat metabolism and storage patterns that determine how much deficit AOD-9604 targets.
Is AOD-9604 the same as HGH?
No. AOD-9604 is a small fragment (amino acids 177-191) of HGH with a tyrosine modification. It retains only the fat-metabolizing activity. Unlike full HGH, it does not stimulate IGF-1, does not promote tissue growth, does not cause insulin resistance, and does not carry proliferative risks. It is a targeted metabolic tool, not a growth agent.
Your next move
Two ways forward with AOD-9604.
Not sure it's for you?
Will AOD-9604 work for your genes — and at what dose?
Your report scores AOD-9604 against your receptor, CYP and pathway variants — likely responder, non-responder, and a sensible starting dose — in minutes.
Analyze my DNA — $99