AOD-9604
Advanced Obesity Drug 9604 (hGH Fragment 177-191)
The fat metabolism peptide
A modified 16-amino-acid fragment of human growth hormone (amino acids 177-191) with a tyrosine substitution. AOD-9604 retains the fat-metabolizing activity of full-length GH without stimulating IGF-1, meaning it promotes lipolysis and inhibits lipogenesis without the growth, insulin resistance, or proliferative risks of HGH.
Key Benefits
Enhanced fat metabolism without IGF-1 elevation
Inhibition of new fat storage (lipogenesis)
Weight management without muscle-wasting effects
Potential cartilage repair and joint support
Mechanism of Action
How AOD-9604 works
AOD-9604 targets fat metabolism through growth-hormone-derived pathways while avoiding systemic growth effects:
- Beta-3 adrenergic receptor activation — stimulates lipolysis (fat breakdown) in adipose tissue by activating the same receptor pathway as the fat-burning region of natural growth hormone
- Lipogenesis inhibition — blocks the conversion of non-fatty food substrates into stored body fat, reducing new fat accumulation independent of caloric intake
- No IGF-1 stimulation — unlike full-length HGH, AOD-9604 does not raise IGF-1 levels, eliminating risks of insulin resistance, acromegaly-like effects, and proliferative concerns
- Cartilage repair signaling — emerging evidence suggests AOD-9604 stimulates proteoglycan synthesis in chondrocytes, which is why it received Australian TGA regulatory consideration for osteoarthritis
Your Genetics & AOD-9604
Genetic variants that affect your response
These SNPs determine how effectively AOD-9604 works for you specifically. A genetic peptide report identifies your variants before you start.
The GHR d3 (exon 3 deletion) polymorphism affects GH receptor sensitivity. d3 carriers have enhanced GH signaling — since AOD-9604 is a GH fragment, receptor sensitivity variants may influence fat-metabolizing response.
The Pro12Ala variant affects adipocyte differentiation and insulin sensitivity. Ala carriers tend to have smaller fat cells and better insulin sensitivity — AOD-9604's lipogenesis inhibition may be more impactful in Pro/Pro individuals with larger, more insulin-resistant adipocytes.
The Trp64Arg variant in the beta-3 adrenergic receptor reduces lipolytic response. Since AOD-9604 acts partly through beta-3 receptor pathways, carriers of the Arg64 variant may have a blunted fat-burning response.
The strongest common genetic risk factor for obesity. AA carriers have higher baseline fat mass and altered energy metabolism — AOD-9604's targeted fat metabolism effect addresses the metabolic component, though FTO also affects appetite regulation.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
15+
Published studies
Animal studies and in vitro data with promising but limited clinical validation
Common Stacks
AOD-9604 is commonly combined with:
Frequently Asked Questions
What is AOD-9604 used for?
AOD-9604 is used for fat loss and weight management. As a modified fragment of human growth hormone, it stimulates fat breakdown (lipolysis) and blocks new fat storage (lipogenesis) without raising IGF-1. This gives it the fat-metabolizing benefit of HGH without the growth, insulin, or proliferative risks.
Does genetics affect AOD-9604 response?
Yes. ADRB3 variants affect the beta-3 adrenergic receptor AOD-9604 acts through — the Trp64Arg variant can blunt lipolytic response. GHR d3 deletion affects growth hormone receptor sensitivity. PPARG and FTO variants influence baseline fat metabolism and storage patterns that determine how much deficit AOD-9604 targets.
Is AOD-9604 the same as HGH?
No. AOD-9604 is a small fragment (amino acids 177-191) of HGH with a tyrosine modification. It retains only the fat-metabolizing activity. Unlike full HGH, it does not stimulate IGF-1, does not promote tissue growth, does not cause insulin resistance, and does not carry proliferative risks. It is a targeted metabolic tool, not a growth agent.
Personalize your protocol
Does AOD-9604 match your DNA?
Upload your existing genetic data or order a kit. Your report scores AOD-9604 against your unique genetic profile — CYP metabolism, receptor variants, pathway markers — in minutes.