DSIP
DSIP (Delta Sleep-Inducing Peptide)
Also called DSIP, delta sleep-inducing peptide
The deep-sleep peptide
DSIP was found in the 1970s in the blood of sleeping rabbits and named after the deep, slow brain waves it seemed to bring on. Fifty years later it is still not clear exactly how it works, or how reliably. People use it for sleep, and reports range from noticeably helpful to nothing at all.
A nine-amino-acid neuropeptide first isolated for its ability to promote delta-wave (deep) sleep. It's used by people chasing better slow-wave sleep and stress resilience. The honest, gene-aware take: DSIP's deep-sleep advantage is tied to specific adenosine-pathway genetics, so whether it's likely to help *you* depends heavily on your own sleep-architecture genes — for many, it's simply not indicated.
- Typical dose
- 100–300 mcg at bedtime
- Availability
- Research-only
Early research, mostly in the lab so far
What people use DSIP for
Reported uses, roughly in order of how often they are the reason someone goes looking. Whether it works for any of them is a separate question, answered under each one.
- Sleep
- The whole reason anyone looks it up. Described as helping people fall asleep and spend more time in deep sleep, without the hangover of a sedative.
- Stress and recovery
- A secondary use, on the basis that it appears to influence stress hormones. Thinly supported.
Mechanism of Action
How DSIP works
DSIP works on the brain's sleep and stress regulation, though its exact targets remain partly unresolved:
- Delta-wave promotion — shifts sleep architecture toward slow-wave (deep) sleep, the restorative stage
- Adenosine / sleep-pressure interaction — its deep-sleep benefit links to the adenosine pathway, which builds and resolves sleep pressure
- Stress-axis modulation — influences HPA-axis and stress-hormone rhythms, with some anxiolytic and chronobiotic effects
- Genotype-gated benefit — the strongest deep-sleep effect tracks with specific adenosine-deaminase genetics; lacking that variant, the expected benefit is much smaller
DSIP dosage calculator
Opens at 100 mcg, from the doses reported for DSIP. Change any box to match your own vial. It works out where to pull the plunger to.
How much is in the vial?
Printed on the label, in milligrams
How much water did you add?
Bacteriostatic water, in millilitres
What dose are you taking?
The dose you already intend to use
Which syringe?
Barrel size, printed on the wrapper
Draw to
2 units
on a 0.5 mL insulin syringe (0.02 mL)
- Strength once mixed
- 5 mg/mL
- Doses in the vial
- 100
10 mg in 2 mL makes 5 mg/mL. A 100 mcg dose is 0.02 mL of that, which is 2 units.
Want a rounder number? Adding 10 mL instead would put this dose at exactly 10 units, which is easier to draw accurately.
This is arithmetic, not advice. It converts a dose you already have into a mark on a syringe. It does not tell you what dose to take, and DSIP is not prescribed by us. Dosing belongs with a qualified clinician.
DSIP side effects: what people reported
Very little reported, which is either because it is gentle or because it does not do very much. Both readings are honest.
What people report
- Grogginess the next morning if taken too late
- Injection-site redness
- Vivid dreams
- Headache
Worth keeping an eye on
- Response varies enormously between people, more than almost anything else here. Plenty report no effect whatsoever
Source: Early human work from the 1980s and reported use since. This is a summary of published findings, not a complete safety profile and not medical advice. DSIP should only be considered with a qualified clinician who knows your history.
Your Genetics & DSIP
The genes involved in how DSIP works
DSIP works through the receptors these genes build, and the genes vary from person to person. Researchers have linked some of that variation to differences in how people respond. A DNA report tells you which versions you carry.
ADA · ••
The rare A allele of this adenosine-deaminase variant is associated with deeper, more intense slow-wave sleep — the trait DSIP targets. The common genotype (full ADA activity) lacks this deep-sleep variant, so the expected DSIP benefit is much weaker.
PER3 · ••
The PER3 variable-number repeat sets chronotype (morning vs evening) and sleep homeostasis. Your chronotype genetics shape whether a chronobiotic/deep-sleep peptide aligns with or fights your natural rhythm.
ADORA2A sets sensitivity to adenosine (the same pathway caffeine blocks). It influences how strongly sleep pressure translates into deep sleep — context for whether DSIP's adenosine-linked effect lands.
The dots after each gene are where your own result goes. Your report fills them in with the two letters you carry at that position.
Which variants do you carry?
Upload your DNA data, or get tested through our partner, to find out.
Commonly combined with
What DSIP is most often paired with, and why:
Epithalon
Circadian StackEmerging EvidenceEpitalon (Ala-Glu-Asp-Gly)
A synthetic tetrapeptide based on the natural pineal gland peptide epithalamin. Epithalon activates telomerase, the enzyme that maintains telomere length, potentially slowing cellular aging. Discovered by Professor Vladimir Khavinson, it remains one of the most studied anti-aging peptides in gerontology.
3
Gene variants
20+
Studies
Selank
Calm-Sleep StackEmerging EvidenceSelank (Tuftsin Analog with Pro-Gly-Pro)
A Russian-developed anxiety peptide built from a fragment of a natural immune molecule, with a short tail added so it survives longer than a few minutes. It is one of very few compounds here with human trials, including a head-to-head against a benzodiazepine, though nearly all of that work was done in Russia and published in Russian.
4
Gene variants
30+
Studies
Sourcing & access
Where to buy DSIP
DSIP is sold as a research compound, not a licensed medicine, so quality and legal status vary widely by country and vendor. If you're sourcing it, treat independent purity testing as non-negotiable.
- Insist on a recent third-party Certificate of Analysis (COA) for the exact batch — labs like Janoshik verify purity and identity.
- Check the legal status where you live before ordering — it differs from country to country.
- Reconstitute correctly with bacteriostatic water and start at a conservative dose.
DSIP
The deep-sleep peptide
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Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Worth knowing before you consider DSIP
Interactions and situations where there is a specific reason to be careful. Where the honest answer is that nobody has studied something, it says so and says what that leaves open.
- The evidence is old and thin
- Most of the human work is decades old, small, and has not been repeated with modern sleep measurement. That is not a scandal, it is just the state of it.
- Persistent insomnia deserves a diagnosis
- Sleep apnoea and a handful of other treatable causes look exactly like ordinary bad sleep, and no peptide will touch them.
Last updated
Frequently Asked Questions
What is DSIP used for?
DSIP (delta sleep-inducing peptide) is used to promote deep, slow-wave sleep and support stress resilience. It shifts sleep architecture toward the restorative delta stage and modulates the stress axis.
Does genetics decide if DSIP works?
Largely, yes. The deep-sleep advantage DSIP targets is tied to a specific adenosine-deaminase (ADA) variant. If you carry the common full-activity genotype rather than the rare deep-sleep allele, the expected benefit is much smaller — so your sleep genetics are worth checking first.
Is DSIP legal?
DSIP is not approved by any major regulator; its human data are old and limited, and it remains a research compound. Access and regulatory status vary by country.
Learn more about DSIP
peptide guides
In depthBest Peptides for Sleep: DSIP vs Epithalon vs Ipamorelin (Which One Matches Your Biology)
12 min read
safety
Are Peptides Legal in the US? 9 Things You Need to Know in 2026
14 min read
peptide guides
Pinealon Peptide: Benefits, Dosage, and What 30 Years of Russian Research Actually Shows
13 min read
Your next move
Two ways forward with DSIP.
Not sure it's for you?
How does DSIP relate to your genes?
Your report scores DSIP against your receptor, pharmacogene and pathway variants and shows the genetic markers relevant to it, with commonly cited dosing information to review with a clinician.
Analyze my DNA — $99Already decided?
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