PT-141
PT-141 (Bremelanotide)
The libido peptide
A melanocortin receptor agonist, FDA-approved as Vyleesi for low sexual desire (HSDD) in premenopausal women and used off-label for libido in both sexes. Unlike Viagra-type drugs that work on blood flow, PT-141 acts centrally in the brain to raise sexual desire itself — a fundamentally different mechanism. Taken on-demand by subcutaneous injection.
- Typical dose
- 1.75 mg as needed
- Availability
- Research-only
Key Benefits
FDA-approved (Vyleesi) — the cleanest evidence in this category
Raises sexual desire centrally, not just blood flow
Works in both men and women
An option when PDE5 inhibitors (Viagra/Cialis) don't help
On-demand dosing rather than daily
Mechanism of Action
How PT-141 works
PT-141 works on desire at its source — the brain — not on the plumbing:
- MC4R / MC3R agonism — activates melanocortin receptors in the hypothalamus, the brain region that initiates sexual motivation and arousal
- Central, not vascular — because it acts on neural desire pathways rather than blood flow, it can work where PDE5 inhibitors (Viagra, Cialis) fall short, and in both men and women
- On-demand kinetics — taken before activity rather than daily; effects build over a few hours
- Class side-effects — transient nausea, flushing and a small rise in blood pressure are the melanocortin-class effects to be aware of
Your Genetics & PT-141
Genetic variants that affect your response
These SNPs determine how effectively PT-141 works for you specifically. A genetic peptide report identifies your variants before you start.
MC4R is PT-141's primary target. Loss-of-function variants here can change melanocortin signaling; wild-type / non-risk genotypes carry no loss-of-function responder or non-responder signal — meaning no genetic reason to expect a blunted response.
A second common MC4R variant. Non-risk genotypes again give no loss-of-function signal, so the receptor PT-141 acts on is intact.
The Met/Met (slow-COMT) genotype clears catecholamines slowly, which can modestly amplify or prolong PT-141's central adrenergic side effects (flushing, nausea, blood-pressure bump) — a tolerability watch-item rather than an efficacy one.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
30+
Published studies
Multiple human clinical trials or CPIC-level pharmacogenomic data
Sourcing & access
Where to buy PT-141
PT-141 is available through licensed telehealth and retail providers. We rank them by price, reviews and a credibility score — so you can find the cheapest source that's actually legitimate.
- Buy only from licensed providers that publish recent third-party purity tests (COAs).
- Compare the total cost — consultation, the compound, and shipping — not just the sticker price.
- Confirm the provider ships to your country and requires a genuine medical intake.
Before you buy: see whether your DNA actually responds to PT-141, and at what dose. Analyze my DNA — $99 →
Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Common Stacks
PT-141 is commonly combined with:
Oxytocin
Intimacy StackModerate EvidenceOxytocin (The Bonding Hormone)
The body's bonding and trust hormone — FDA-approved as Pitocin for labor, and used off-label intranasally for social connection, anxiety and intimacy. Oxytocin acts in the brain to lower social-threat responses and deepen feelings of trust and closeness. Crucially, response is strongly gene-stratified: your OXTR receptor genotype sets how much you actually feel it.
4
Gene variants
40+
Studies
Frequently Asked Questions
What is PT-141 used for?
PT-141 (bremelanotide) is used to increase sexual desire. It's FDA-approved as Vyleesi for HSDD in premenopausal women and used off-label for low libido and erectile difficulty in men. It acts on the brain's melanocortin system rather than on blood flow.
How is PT-141 different from Viagra?
Viagra and Cialis (PDE5 inhibitors) improve blood flow to enable an erection. PT-141 works upstream — in the brain — to increase desire itself. That's why it can help in cases where blood-flow drugs don't, and why it works in women as well as men.
Does genetics affect PT-141 response?
Your MC4R genotype is the key — PT-141 targets the MC4R receptor, so loss-of-function variants are what would matter. COMT (Met/Met) genetics don't change whether it works, but can make its central side-effects more pronounced. A genetic report flags both.
Learn More About PT-141
Your next move
Two ways forward with PT-141.
Not sure it's for you?
Will PT-141 work for your genes — and at what dose?
Your report scores PT-141 against your receptor, CYP and pathway variants — likely responder, non-responder, and a sensible starting dose — in minutes.
Analyze my DNA — $99Already decided?
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