VIP
VIP (Vasoactive Intestinal Peptide)
The anti-inflammatory regulator
A 28-amino-acid signaling peptide (studied pharmaceutically as aviptadil) that acts as a powerful endogenous anti-inflammatory and immune regulator. It's been explored intranasally for chronic inflammatory and biotoxin-illness states. The honest framing: VIP suppresses inflammation, so it only makes sense if your inflammation is genuinely over-active — for a genetically 'quiet' immune set-point, there's little to suppress.
Key Benefits
Potent endogenous anti-inflammatory and immune-regulatory action
Rebalances cytokines away from a pro-inflammatory state
Explored for chronic inflammatory and biotoxin illness
Vascular and airway smooth-muscle relaxation
Most relevant to a genuinely over-active inflammatory profile
Mechanism of Action
How VIP works
VIP is a broad immune and vascular regulator:
- VPAC receptor signaling — activates VPAC1/VPAC2 receptors to shift immune cells toward an anti-inflammatory, regulatory state
- Cytokine rebalancing — suppresses pro-inflammatory mediators (TNF-α, IL-6) while supporting regulatory signaling, calming an over-active inflammatory response
- Vascular and hormonal effects — relaxes vascular and airway smooth muscle and influences pulmonary and endocrine function (the basis of aviptadil's respiratory research)
- Only useful if inflammation is high — because its job is to damp inflammation, a quiet, well-regulated immune set-point has little for VIP to act on
Your Genetics & VIP
Genetic variants that affect your response
These SNPs determine how effectively VIP works for you specifically. A genetic peptide report identifies your variants before you start.
The NLRP3 inflammasome is a master driver of inflammation. Risk variants mean an over-active inflammatory tendency that an anti-inflammatory like VIP could target; non-risk genotypes indicate a quiet set-point with little to suppress.
The -308 promoter variant raises TNF-α output in A-allele carriers. Higher baseline TNF tone is the inflammatory background where VIP's suppression is justified; GG (normal) is not.
IL-10 is the body's own anti-inflammatory brake. Your IL-10 genotype indicates how strong your built-in regulation already is — high baseline regulation leaves less room for additional suppression.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
25+
Published studies
Pathway-based inference and early research. Use with appropriate caution
Common Stacks
VIP is commonly combined with:
Frequently Asked Questions
What is VIP used for?
VIP (vasoactive intestinal peptide) is a potent endogenous anti-inflammatory studied — often intranasally — for chronic inflammatory states and biotoxin illness, and pharmaceutically (as aviptadil) for respiratory conditions. It calms an over-active immune response.
Does genetics affect whether VIP helps?
Yes, decisively. VIP suppresses inflammation, so it's most useful when your inflammation is genuinely high. Markers like NLRP3, TNF (rs1800629) and IL10 reveal whether your immune set-point runs hot or quiet — and a quiet profile gives VIP little to act on.
Is VIP legal?
VIP is not approved for general use; aviptadil has been studied in specific diseases under research/trial settings, and intranasal use is off-label/research. Access and regulatory status vary by country.
Learn More About VIP
Your next move
Two ways forward with VIP.
Not sure it's for you?
Will VIP work for your genes — and at what dose?
Your report scores VIP against your receptor, CYP and pathway variants — likely responder, non-responder, and a sensible starting dose — in minutes.
Analyze my DNA — $99