PT-141: Bremelanotide Is An Amazing New Drug for Erectile Dysfunction [2019]
A solo creator explains PT-141 (bremelanotide), covers its history, mechanism, sourcing and injection steps, and shares his own months-long experience. He says he is not a physician.
Key moments
Tap a moment to play the video from there.
- 0:00Introduction to the PT-141 reviewHitchings introduces bremelanotide as a touted treatment for erectile dysfunction and says he will cover its history, sourcing, dosing, effects and his own experience.
- 1:05Peptide chemistry and MSH backgroundHe describes PT-141 as a cyclic peptide analog of alpha MSH and lists other roles of melanocyte stimulating hormones. He defines agonist, antagonist and inverse agonist.
- 2:52Origins in tanning researchHe recounts research from the 1960s to the 1980s and the Arizona work on Melanotan analogs. He tells the story of an eight-hour erection after a double dose.
- 5:04How it differs from Viagra and CialisHe explains that the common pills work on blood flow in erectile tissue, while he says PT-141 works on libido and desire for 24 to 48 hours.
- 6:14Where to buy and what it costsHe says it is not available in the US by prescription and describes buying from online suppliers, mostly Chinese. He gives per vial and per box prices.
- 8:16Mixing and injecting step by stepHe describes reconstituting the freeze-dried powder with bacteriostatic water and drawing a dose. He then explains injecting near the belly button with an insulin needle.
- 11:59Side effects and toleranceHe reports slight nausea after injecting that faded with every other day use. He also says it became more effective and kicked in faster over time.
- 13:44Personal experience in detailHe describes his dose escalation to 0.3 milliliters, heightened desire and prolonged erections. He mentions worry about priapism and says men on a forum report similar effects.
- 15:36Conclusion and caveatsHe sums up the video, says he is not a physician and will not recommend it to others, and says he personally loved it.
What the video says
Lance Hitchings presents a solo review of PT-141, also called bremelanotide, which he describes as a drug for erectile dysfunction. He opens with the chemistry, calling it a cyclic peptide related to the melanocyte stimulating hormones. He notes that these hormones affect skin pigment, appetite, inflammation, water and salt balance, and sexual behavior. He says PT-141 acts as an agonist at melanocortin receptors, mainly MC3 and MC4, and that MC4 helps regulate sexual behavior and male erectile function.
He then walks through the history as he understands it. He says early research on alpha MSH pointed to sexual arousal, and that University of Arizona scientists later worked on tanning analogs. He says one of them, Mac Hadley, injected himself with twice the intended dose of Melanotan 2 and had an eight-hour erection. Hitchings says a company later developed bremelanotide, which he describes as a likely metabolite of Melanotan 2, first as a nasal spray and then as an injection after the FDA halted trials over blood pressure increases. He says a new drug application was filed in June 2018. He contrasts the drug with Viagra, Levitra and Cialis, saying those act on erectile tissue while PT-141 acts on desire.
The middle section is practical. Hitchings says PT-141 is not sold in the US with or without a prescription, but that many online sellers, especially Chinese suppliers, offer it. He gives price ranges. He then details how he reconstitutes a 10 milligram vial with bacteriostatic water and injects it near the belly button, including the syringe, wipes and technique he uses.
He closes with his own account over a few months. He describes mild nausea after injections that faded with every other day use, onset that shortened from about eight hours to two to four, and a dose that settled at 0.3 milliliters. He reports strong desire lasting a couple of days and erections lasting much of the night and day. He says he is not a physician, does not recommend it to anyone, and personally loved it.
On each compound
PT-1411:05
Hitchings describes PT-141 (bremelanotide) as a melanocortin receptor agonist, mainly at MC3 and MC4, that he says acts on desire rather than blood flow. He reports his own use by injection, with mild nausea, a dose of about 0.3 milliliters and prolonged erections.
See how your DNA reads PT-141Melanotan II3:11
He says Melanotan 2 was developed as a sunless tanning analog at the University of Arizona. He says a scientist who injected twice the intended dose had an eight-hour erection, and that bremelanotide is thought to be a metabolite of it.
See how your DNA reads Melanotan IIWhat this video doesn’t settle
- It is one person's experience over a few months, with no control group, no medical monitoring and no comparison to other treatments.
- The history, trial details and trade name are recounted from memory, and Hitchings says he is unsure of some of them.
- Doses, product purity and online sourcing are described without any testing or verification of what the vials contain.
Questions this video answers
What is PT-141 according to Lance Hitchings?
He describes it as a cyclic peptide analog of alpha MSH that activates melanocortin receptors, mainly MC3 and MC4. He says MC4 helps regulate sexual behavior and male erectile function.
How does PT-141 differ from Viagra, Levitra and Cialis in this video?
Hitchings says those three block the PDE5 enzyme and act directly on erectile tissue. He says PT-141 instead works on libido and sex drive, with effects lasting 24 to 48 hours.
What dose and injection method does Hitchings describe?
He says he reconstitutes a 10 milligram vial with 1 milliliter of bacteriostatic water and injects near the belly button with a half-inch 30 gauge insulin needle. He started at 0.1 milliliters, found no effect, and settled at about 0.3 milliliters, and he tells viewers to find their own dose.
What side effects does Hitchings report from PT-141?
He reports slight nausea right after injecting, which he says faded when he injected every other day. He also reports long-lasting erections, including overnight and into the next day, and says he worried about priapism.
Is PT-141 approved, according to the video?
Hitchings says it was still under development by Palatin Technologies and not available in the US for purchase with or without a prescription. He says a new drug application was filed in June 2018 and that he is unsure of the trade name.
Video by Lance Hitchings on YouTube, embedded as published. The summary is written by PeptidesDNA from the video; every claim in it is the speaker’s. Not affiliated with or endorsed by the creator. Not medical advice.
