TL;DR
- 1.PlexusDx: 57 SNPs, 49 peptides, US-based, also offers blood testing. Broader platform.
- 2.PeptidesDNA: 120 SNPs, 25+ peptides, EU-based, CYP metabolism panel, evidence-tiered scoring. Deeper per-peptide analysis.
- 3.PeptidesDNA has a $99 upload option if you already have 23andMe/AncestryDNA data. PlexusDx uses their own kit.
- 4.PlexusDx wins on breadth + blood testing integration. PeptidesDNA wins on depth + price + data uploads.
Until recently, "genetic peptide testing" wasn't really a category. In 2026, two companies have launched dedicated products in this space: PlexusDx (based in the US) and PeptidesDNA (EU-based, shipping worldwide). If you're considering a genetic test to guide your peptide protocol, here's how they compare.
Disclosure: This comparison is published by PeptidesDNA. We've made every effort to be accurate and fair. We encourage you to verify claims on PlexusDx's website directly.
How do PlexusDx and PeptidesDNA compare feature by feature?
| Feature | PlexusDx | PeptidesDNA |
|---|---|---|
| SNPs analyzed | 57 | 120 |
| Peptides covered | 49 | 25+ |
| CYP metabolism panel | Not featured | CYP2D6, CYP3A4, CYP2C19, CYP2C9 |
| Evidence tiering | Not explicitly tiered | Tier 1 / Tier 2 / Tier 3 per association |
| Blood testing | Yes — hormones, methylation, metabolic | Genetic only |
| Upload existing DNA | Own kit required | 23andMe, AncestryDNA, MyHeritage, Nebula |
| Upload price | N/A | $99 one-time |
| Kit price | Check plexusdx.com | $299 one-time |
| Geography | US-focused | EU-based, ships worldwide, GDPR-compliant |
| Report format | Online portal (HIPAA) | PDF download + dashboard |
PlexusDx covers more peptides (49 vs 25+). PeptidesDNA covers more genetic markers per peptide (120 SNPs vs 57) and includes CYP metabolism profiling — the most clinically relevant factor for practical dosing decisions. More peptides isn't always better; depth of analysis per peptide matters for protocol design.
Where PlexusDx wins
PlexusDx integrates blood biomarker testing alongside genetics — hormones, methylation panels, metabolic markers in one unified portal. This gives a more complete biological picture. If you want both genetic and blood data in one platform, PlexusDx delivers that. PeptidesDNA is genetic testing only.
Who Should Choose PlexusDx?
- You want genetic + blood testing in one platform
- You want the broadest peptide coverage (49 peptides)
- You're US-based and prefer a CLIA-certified lab
- You're also interested in their methylation, hormone, or cognition tests
Who Should Choose PeptidesDNA?
- You want the deepest per-peptide analysis (120 SNPs)
- You need a CYP metabolism panel for dosing and drug interaction assessment
- You already have 23andMe/AncestryDNA data and want a $99 upload analysis
- You want evidence-tiered scoring so you know which results are clinically proven vs. exploratory
- You're in Europe and need GDPR-compliant data handling + EU peptide availability context
- You want a one-time purchase without ongoing subscription requirements
Breadth vs. depth — two valid approaches to a new category.
PlexusDx takes the broader platform approach: genetics + blood testing, multiple test types, US lab infrastructure. PeptidesDNA takes the specialist approach: deeper SNP coverage (120 vs 57), CYP metabolism panels, evidence tiering, $99 upload option, and EU-native GDPR compliance. If you want a comprehensive health testing platform, PlexusDx is worth evaluating. If your primary goal is peptide protocol optimization with the deepest analysis at the lowest price — PeptidesDNA is built specifically for that.
Your genetics affect your peptide response.
Find out which peptides align with your DNA before you start any protocol.
Frequently asked questions
Is PlexusDx better than PeptidesDNA?
It depends on what you prioritize. PlexusDx offers more peptides (49 vs 25+) and integrates blood testing alongside genetics — a genuine advantage. PeptidesDNA offers more SNPs per peptide (120 vs 57), dedicated CYP metabolism panels, evidence-tiered scoring, and a $99 upload option for existing DNA data. PlexusDx is US-focused; PeptidesDNA ships globally and is GDPR-compliant.
Can I upload my 23andMe data to PlexusDx?
PlexusDx's current platform appears to use their own testing kits rather than accepting uploads from other providers. PeptidesDNA accepts raw data uploads from 23andMe (v5), AncestryDNA, MyHeritage, and Nebula Genomics, so if you already have DNA data you can get a peptide report for $99 without ordering another kit.
Which test covers more peptides?
PlexusDx covers 49 peptides across 14 pathways. PeptidesDNA covers 25+ peptides across 12 pathways. However, PeptidesDNA analyzes more SNPs per peptide (120 vs 57 total) and includes CYP metabolizer profiling that PlexusDx doesn't emphasize. More peptides isn't necessarily better — depth of analysis per peptide matters for practical protocol decisions.
Which genetic peptide test is cheaper?
PeptidesDNA offers the lowest entry point at $99 for upload analysis of existing DNA data (23andMe, AncestryDNA, etc.). Their saliva kit is $299. PlexusDx pricing varies by test — check plexusdx.com for current pricing. Both are significantly cheaper than SelfDecode's $418+/year subscription model for peptide-related genetic analysis.
This article is for informational and educational purposes only. It is not medical advice and does not diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare professional before starting any peptide protocol. Individual results vary.