Hexarelin
Hexarelin (Examorelin)
The most potent GHRP — with a cardiac side
A potent hexapeptide GH secretagogue closely related to the GHRP family, notable for the strongest acute GH release of the group and a distinct action at the CD36 receptor that gives it documented cardioprotective effects. Hexarelin's potency comes with faster receptor desensitization, so it is typically cycled rather than run continuously.
- Half-life
- ~20–70 min
- Route
- Subcutaneous injection
- Typical dose
- 100 mcg 1–2x/day (cycled)
- Availability
- Research-only
Key Benefits
Strongest acute GH pulse among the GHRPs
Cardioprotective signaling via CD36
Improved recovery and body composition
Supports deep sleep
Effective at low doses due to high potency
Mechanism of Action
How Hexarelin works
Hexarelin acts through two receptors — the ghrelin receptor and CD36:
- Ghrelin receptor (GHS-R1a) activation — produces the most potent acute GH pulse of the GHRP family by strongly activating pituitary somatotrophs.
- CD36 binding (cardiac) — uniquely engages the CD36 scavenger receptor in cardiac and vascular tissue, the basis for hexarelin's documented cardioprotective and anti-ischemic effects independent of GH.
- Receptor desensitization — its potency drives faster GHS-R1a downregulation than milder secretagogues, so hexarelin is usually pulsed in short cycles to preserve responsiveness.
- Secondary hormones — can raise cortisol and prolactin at higher doses; conservative dosing keeps these effects in check.
Your Genetics & Hexarelin
Genetic variants that affect your response
These SNPs determine how effectively Hexarelin works for you specifically. A genetic peptide report identifies your variants before you start.
Variants in the growth hormone secretagogue receptor gene change receptor density and signaling. Lower GHSR expression reduces the targets for hexarelin and blunts the GH pulse.
CD36 mediates hexarelin's cardiac and metabolic effects. Common CD36 variants reduce receptor expression, which may attenuate the cardioprotective and lipid-handling actions that distinguish hexarelin from other GHRPs.
The GHR exon 3 deletion increases downstream GH sensitivity, so d3 carriers translate hexarelin's potent pulse into greater IGF-1 output at a given dose.
Somatostatin tone limits GH release. Higher-tone variants can partially offset even hexarelin's strong pulse, making timing and cycling more important.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
30+
Published studies
Published human or robust animal studies with clear mechanistic rationale
Sourcing & access
Where to buy Hexarelin
Hexarelin is sold as a research compound, not a licensed medicine, so quality and legal status vary widely by country and vendor. If you're sourcing it, treat independent purity testing as non-negotiable.
- Insist on a recent third-party Certificate of Analysis (COA) for the exact batch — labs like Janoshik verify purity and identity.
- Check the legal status where you live before ordering — it differs from country to country.
- Reconstitute correctly with bacteriostatic water and start at a conservative dose.
Swiss Chems is a US research-chemical supplier that publishes third-party Certificates of Analysis. Sold for research use only — check your local laws.
Before you buy: see whether your DNA actually responds to Hexarelin, and at what dose. Analyze my DNA — $99 →
Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you), and providers we partner with are listed first. Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Common Stacks
Hexarelin is commonly combined with:
CJC-1295
GH Synergy StackModerate EvidenceCJC-1295 (Modified GRF 1-29)
A 29-amino-acid growth hormone releasing hormone (GHRH) analog with enhanced stability. CJC-1295 extends the duration of natural GH pulses without disrupting pulsatile release patterns, providing sustained elevation of growth hormone and IGF-1 for recovery, body composition, and anti-aging.
4
Gene variants
30+
Studies
Ipamorelin
lower-desensitization alternativeModerate EvidenceIpamorelin Acetate
A pentapeptide ghrelin receptor agonist that triggers clean, selective growth hormone pulses without raising cortisol or prolactin. Ipamorelin is considered the most selective GH secretagogue available, making it the preferred choice for those prioritizing minimal side effects alongside GH optimization.
4
Gene variants
40+
Studies
BPC-157
Recovery StackModerate EvidenceBody Protection Compound 157
A 15-amino-acid peptide derived from human gastric juice. The most-researched peptide for tissue repair, gut healing, and injury recovery. Works through nitric oxide signaling, angiogenesis, and collagen stimulation.
4
Gene variants
100+
Studies
Frequently Asked Questions
Why is Hexarelin cycled rather than run continuously?
Hexarelin is the most potent GHRP, and that potency causes faster desensitization of the ghrelin receptor than milder secretagogues. Running it continuously blunts its own effect over time, so it is typically used in short pulses or cycles to preserve responsiveness.
What makes Hexarelin different from other GHRPs?
Besides the strongest acute GH release, hexarelin uniquely binds the CD36 receptor in heart and vascular tissue, giving it cardioprotective and anti-ischemic effects that the other GHRPs don't share. Your CD36 genotype influences how pronounced these cardiac effects are.
Does genetics affect Hexarelin response?
Yes. GHSR variants set receptor availability for the GH pulse, CD36 variants shape the cardiac and metabolic effects, the GHR d3 polymorphism affects downstream GH sensitivity, and somatostatin variants influence pulse suppression. A genetic peptide report profiles these for you.
Learn More About Hexarelin
Your next move
Two ways forward with Hexarelin.
Not sure it's for you?
Will Hexarelin work for your genes — and at what dose?
Your report scores Hexarelin against your receptor, CYP and pathway variants — likely responder, non-responder, and a sensible starting dose — in minutes.
Analyze my DNA — $99Already decided?
Get Hexarelin from Swiss Chems.
A US research-chemical supplier with third-party Certificates of Analysis. Sold for research use only — check your local laws before ordering.
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