Hexarelin
Hexarelin (Examorelin)
Also called Hexarelin, Examorelin, EP-23905
One of the most potent GHRPs — with a cardiac side
Hexarelin is the strongest growth hormone releaser in this family, and it has the shortest useful life because of it. Your pituitary stops responding within weeks. It also has a genuinely unusual second property: it appears to act directly on heart tissue, independently of growth hormone.
A potent hexapeptide GH secretagogue closely related to the GHRP family, notable for one of the strongest acute GH releases of the group and a distinct action at the CD36 receptor that gives it documented cardioprotective effects. Hexarelin's potency comes with faster receptor desensitization, so it is typically cycled rather than run continuously.
- Half-life
- ~20–70 min
- Route
- Subcutaneous injection
- Typical dose
- 100 mcg 1–2x/day (cycled)
- Availability
- Research-only
Studied in people, and well studied in animals
What people use Hexarelin for
Reported uses, roughly in order of how often they are the reason someone goes looking. Whether it works for any of them is a separate question, answered under each one.
- A short, strong growth hormone push
- What it is best at, and only briefly. It produces a bigger release than ipamorelin or the GHRPs, which is why people reach for it, and the response fades fast enough that it is used in short blocks rather than continuously.
- Heart tissue
- The genuinely interesting part. It binds a receptor in the heart directly, and animal work suggests protective effects on heart muscle that do not depend on growth hormone at all. Studied, not established.
Mechanism of Action
How Hexarelin works
Hexarelin acts through two receptors — the ghrelin receptor and CD36:
- Ghrelin receptor (GHS-R1a) activation — produces one of the strongest acute GH pulses of the GHRP family by strongly activating pituitary somatotrophs.
- CD36 binding (cardiac) — uniquely engages the CD36 scavenger receptor in cardiac and vascular tissue, the basis for hexarelin's documented cardioprotective and anti-ischemic effects independent of GH.
- Receptor desensitization — its potency drives faster GHS-R1a downregulation than milder secretagogues, so hexarelin is usually pulsed in short cycles to preserve responsiveness.
- Secondary hormones — can raise cortisol and prolactin at higher doses; conservative dosing keeps these effects in check.
Hexarelin dosage calculator
Opens at 100 mcg, from the doses reported for Hexarelin. Change any box to match your own vial. It works out where to pull the plunger to.
How much is in the vial?
Printed on the label, in milligrams
How much water did you add?
Bacteriostatic water, in millilitres
What dose are you taking?
The dose you already intend to use
Which syringe?
Barrel size, printed on the wrapper
Draw to
2 units
on a 0.5 mL insulin syringe (0.02 mL)
- Strength once mixed
- 5 mg/mL
- Doses in the vial
- 100
10 mg in 2 mL makes 5 mg/mL. A 100 mcg dose is 0.02 mL of that, which is 2 units.
Want a rounder number? Adding 10 mL instead would put this dose at exactly 10 units, which is easier to draw accurately.
This is arithmetic, not advice. It converts a dose you already have into a mark on a syringe. It does not tell you what dose to take, and Hexarelin is not prescribed by us. Dosing belongs with a qualified clinician.
Hexarelin side effects: what people reported
It is the least selective compound in this family, which is the trade-off for its strength: it drags cortisol and prolactin up alongside growth hormone, and people feel that.
What most people notice
- Strong hunger shortly after a dose
- A head rush or flushing on injecting
- Tiredness
- Water retention and puffiness
- Injection-site redness
Worth keeping an eye on
- Desensitisation. This is the defining problem: the response drops off within weeks and no amount of extra dose brings it back, so it is cycled rather than run continuously
- Raised cortisol, which is the opposite of what most people are after
- Raised prolactin, which at higher doses can affect libido and, in men, breast tissue
- Tingling hands from fluid retention
Dose matters. The cortisol and prolactin rise scale with dose, which is the main argument against using more.
Source: Clinical pharmacology studies and reported use. This is a summary of published findings, not a complete safety profile and not medical advice. Hexarelin should only be considered with a qualified clinician who knows your history.
Your Genetics & Hexarelin
The genes involved in how Hexarelin works
Hexarelin works through the receptors these genes build, and the genes vary from person to person. Researchers have linked some of that variation to differences in how people respond. A DNA report tells you which versions you carry.
GHSR · ••
Variants in the growth hormone secretagogue receptor gene change receptor density and signaling. Lower GHSR expression reduces the targets for hexarelin and blunts the GH pulse.
CD36 mediates hexarelin's cardiac and metabolic effects. Common CD36 variants reduce receptor expression, which may attenuate the cardioprotective and lipid-handling actions that distinguish hexarelin from other GHRPs.
GHR · ••
The GHR exon 3 deletion increases downstream GH sensitivity, so d3 carriers translate hexarelin's potent pulse into greater IGF-1 output at a given dose.
Somatostatin tone limits GH release. Higher-tone variants can partially offset even hexarelin's strong pulse, making timing and cycling more important.
The dots after each gene are where your own result goes. Your report fills them in with the two letters you carry at that position.
Which variants do you carry?
Upload your DNA data, or get tested through our partner, to find out.
Commonly combined with
What Hexarelin is most often paired with, and why:
CJC-1295
GH Synergy StackModerate EvidenceCJC-1295 (Modified GRF 1-29)
A copy of the brain signal that tells the pituitary to release growth hormone, rewritten so the enzyme that normally destroys it in minutes cannot. Before you read any dose, check which version you have: with DAC it keeps growth hormone up for days, without DAC it produces a short pulse, and nearly every blend sold with ipamorelin contains the second one.
4
Gene variants
30+
Studies
Ipamorelin
lower-desensitization alternativeModerate EvidenceIpamorelin Acetate
Presses the same switch your stomach uses to say it is empty, the one that also triggers a growth hormone release, but largely without the hunger. Its selling point is what it does not do: older peptides in its family also pushed up cortisol and prolactin, and this one mostly stops at growth hormone. It is almost always sold blended with CJC-1295.
4
Gene variants
40+
Studies
BPC-157
Recovery StackModerate EvidenceBody Protection Compound 157
BPC-157 is the peptide people reach for when something will not heal. Tendons, ligaments, a gut that has been irritated by painkillers, an injury that has stalled. It is a short chain of amino acids copied from part of a protein your stomach already makes, and the animal research on it is unusually consistent for this category: across a lot of separate rat studies, injured tissue healed faster than it did without it. The gap is that this has largely not been repeated in people, and it is not an approved medicine, so nobody is checking what is in the vial you buy.
3
Gene variants
19+
Studies
Sourcing & access
Where to buy Hexarelin
Hexarelin is sold as a research compound, not a licensed medicine, so quality and legal status vary widely by country and vendor. If you're sourcing it, treat independent purity testing as non-negotiable.
- Insist on a recent third-party Certificate of Analysis (COA) for the exact batch — labs like Janoshik verify purity and identity.
- Check the legal status where you live before ordering — it differs from country to country.
- Reconstitute correctly with bacteriostatic water and start at a conservative dose.
Hexarelin
One of the most potent GHRPs — with a cardiac side
$21.56at Swiss Chems
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Before you buy: see whether your DNA actually responds to Hexarelin, and at what dose. Analyze my DNA — $99 →
Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Worth knowing before you consider Hexarelin
Interactions and situations where there is a specific reason to be careful. Where the honest answer is that nobody has studied something, it says so and says what that leaves open.
- It stops working, and that is the point of the compound
- Not a rumour. Response falls sharply within a few weeks of continuous use. Anyone selling it as a daily long-term protocol is either misinformed or hoping you are.
- It is the dirtiest of the family
- The reason ipamorelin displaced it. If you want a growth hormone nudge without cortisol and prolactin coming along, this is the wrong compound.
Last updated
Frequently Asked Questions
Why is Hexarelin cycled rather than run continuously?
Hexarelin is one of the most potent GHRPs, and that potency causes faster desensitization of the ghrelin receptor than milder secretagogues. Running it continuously blunts its own effect over time, so it is typically used in short pulses or cycles to preserve responsiveness.
What makes Hexarelin different from other GHRPs?
Besides its strong acute GH release, hexarelin uniquely binds the CD36 receptor in heart and vascular tissue, giving it cardioprotective and anti-ischemic effects that the other GHRPs don't share. Your CD36 genotype influences how pronounced these cardiac effects are.
Does genetics affect Hexarelin response?
Yes. GHSR variants set receptor availability for the GH pulse, CD36 variants shape the cardiac and metabolic effects, the GHR d3 polymorphism affects downstream GH sensitivity, and somatostatin variants influence pulse suppression. A genetic peptide report profiles these for you.
Learn more about Hexarelin
9 guides mention Hexarelin→safety
The Truth About Peptide Cycling: When to Pause and When to Push
11 min read
peptide guides
In depthHexarelin: 9 Things Nobody Tells You About the Strongest GHRP
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how it works
How Long Does It Actually Take for GH Receptors to Reset After a Peptide Cycle? (Week by Week)
12 min read
peptide guides
MK-677 Long-Term Results: What 2 Years of Trials Actually Show
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peptide guides
GHRP-2 Dosage Protocol: Why Pharma Abandoned It and What That Means for Your Cycle
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stacking
Ipamorelin CJC-1295 Stack: Dosage Guide by Genotype and Bloodwork
13 min read
Your next move
Two ways forward with Hexarelin.
Not sure it's for you?
How does Hexarelin relate to your genes?
Your report scores Hexarelin against your receptor, pharmacogene and pathway variants and shows the genetic markers relevant to it, with commonly cited dosing information to review with a clinician.
Analyze my DNA — $99Already decided?
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A US research-chemical supplier with third-party Certificates of Analysis. Sold for research use only — check your local laws before ordering.
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