BPC-157
Body Protection Compound 157
The healing peptide
A 15-amino-acid peptide derived from human gastric juice. The most-researched peptide for tissue repair, gut healing, and injury recovery. Works through nitric oxide signaling, angiogenesis, and collagen stimulation.
Key Benefits
Accelerated tendon and ligament repair
Gut mucosal protection and ulcer healing
Neuroprotective effects (dopaminergic and serotonergic systems)
Counteraction of NSAID-induced gut damage
Wound healing acceleration in skin and muscle
Mechanism of Action
How BPC-157 works
BPC-157 works through four simultaneous pathways:
- Nitric oxide signaling — upregulates eNOS, widening blood vessels and increasing blood flow to injured tissue
- Angiogenesis — stimulates VEGF, growing new blood vessels where blood supply is limited (tendons, ligaments)
- Growth hormone receptor upregulation — increases GH receptor expression in tendon fibroblasts, making tissue more responsive to your own growth hormone
- Anti-inflammatory modulation — shifts TNF-alpha, IL-6, and IL-10 balance toward healing resolution without suppressing inflammation entirely
Your Genetics & BPC-157
Genetic variants that affect your response
These SNPs determine how effectively BPC-157 works for you specifically. A genetic peptide report identifies your variants before you start.
Reduces baseline NO production by 20-30%. BPC-157's NO-boosting effect may be proportionally more impactful if you carry this variant.
Determines clearance speed. Poor metabolizers keep BPC-157 longer — potentially needing lower doses. Ultra-rapid metabolizers may clear it too fast.
The Sp1 polymorphism affects baseline collagen density. Lower collagen = BPC-157 targets a bigger deficit, potentially showing more dramatic healing results.
Affects matrix metalloproteinase activity — the enzymes that break down old tissue for new tissue to replace it. Determines baseline remodeling speed.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
100+
Published studies
Published human or robust animal studies with clear mechanistic rationale
Common Stacks
BPC-157 is commonly combined with:
Frequently Asked Questions
What is BPC-157 used for?
BPC-157 is primarily used for tissue repair — tendons, ligaments, gut lining, and muscle. It's the most popular peptide for injury recovery, post-surgical healing, and gut conditions like ulcers and IBD. It works through nitric oxide signaling, angiogenesis, and collagen stimulation.
Does genetics affect BPC-157 response?
Yes. Your NOS3 gene variants affect the nitric oxide pathway BPC-157 activates. CYP3A4 metabolizer status determines clearance speed and dosing considerations. COL1A1 variants influence collagen synthesis response. A genetic peptide report identifies these factors before you start.
Is BPC-157 legal?
As of February 2026, BPC-157 is being reclassified to Category 1 by the FDA, restoring compounding pharmacy access in the US. In the EU, it is available as a research compound. Regulatory status varies by country.
Learn More About BPC-157
Personalize your protocol
Does BPC-157 match your DNA?
Upload your existing genetic data or order a kit. Your report scores BPC-157 against your unique genetic profile — CYP metabolism, receptor variants, pathway markers — in minutes.