BPC-157
Body Protection Compound 157
The healing peptide
A 15-amino-acid peptide derived from human gastric juice. The most-researched peptide for tissue repair, gut healing, and injury recovery. Works through nitric oxide signaling, angiogenesis, and collagen stimulation.
- Route
- Subcutaneous
- Typical dose
- 250–500 mcg/day
- Availability
- Research-only
Key Benefits
Accelerated tendon and ligament repair
Gut mucosal protection and ulcer healing
Neuroprotective effects (dopaminergic and serotonergic systems)
Counteraction of NSAID-induced gut damage
Wound healing acceleration in skin and muscle
Mechanism of Action
How BPC-157 works
BPC-157 works through four simultaneous pathways:
- Nitric oxide signaling — upregulates eNOS, widening blood vessels and increasing blood flow to injured tissue
- Angiogenesis — stimulates VEGF, growing new blood vessels where blood supply is limited (tendons, ligaments)
- Growth hormone receptor upregulation — increases GH receptor expression in tendon fibroblasts, making tissue more responsive to your own growth hormone
- Anti-inflammatory modulation — shifts TNF-alpha, IL-6, and IL-10 balance toward healing resolution without suppressing inflammation entirely
Your Genetics & BPC-157
Genetic variants that affect your response
These SNPs determine how effectively BPC-157 works for you specifically. A genetic peptide report identifies your variants before you start.
Reduces baseline NO production by 20-30%. BPC-157's NO-boosting effect may be proportionally more impactful if you carry this variant.
Determines clearance speed. Poor metabolizers keep BPC-157 longer — potentially needing lower doses. Ultra-rapid metabolizers may clear it too fast.
The Sp1 polymorphism affects baseline collagen density. Lower collagen = BPC-157 targets a bigger deficit, potentially showing more dramatic healing results.
Affects matrix metalloproteinase activity — the enzymes that break down old tissue for new tissue to replace it. Determines baseline remodeling speed.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
100+
Published studies
Published human or robust animal studies with clear mechanistic rationale
Sourcing & access
Where to buy BPC-157
BPC-157 is sold as a research compound, not a licensed medicine, so quality and legal status vary widely by country and vendor. If you're sourcing it, treat independent purity testing as non-negotiable.
- Insist on a recent third-party Certificate of Analysis (COA) for the exact batch — labs like Janoshik verify purity and identity.
- Check the legal status where you live before ordering — it differs from country to country.
- Reconstitute correctly with bacteriostatic water and start at a conservative dose.
Swiss Chems is a US research-chemical supplier that publishes third-party Certificates of Analysis. Sold for research use only — check your local laws.
Before you buy: see whether your DNA actually responds to BPC-157, and at what dose. Analyze my DNA — $99 →
Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Common Stacks
BPC-157 is commonly combined with:
TB-500
Wolverine StackEmerging EvidenceThymosin Beta-4 (Fragment)
A 43-amino-acid peptide identical to the active region of Thymosin Beta-4, the most abundant actin-binding protein in the body. TB-500 promotes cell migration, blood vessel formation, and tissue repair systemically — reaching injuries that localized treatments miss.
4
Gene variants
50+
Studies
GHK-Cu
Repair StackModerate EvidenceGlycyl-L-Histidyl-L-Lysine Copper Complex
A naturally occurring copper-binding tripeptide that declines with age. GHK-Cu resets gene expression toward a younger pattern, stimulates collagen synthesis, activates antioxidant defenses, and promotes tissue remodeling across skin, bone, and connective tissue.
KPV
Gut StackEmerging EvidenceKPV (Lys-Pro-Val)
A tripeptide derived from the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH). KPV retains the potent anti-inflammatory properties of the parent hormone without melanogenic (skin-darkening) effects. It targets gut inflammation through MC1R signaling and NF-kB suppression, making it a focused tool for IBD, colitis, and intestinal permeability.
4
Gene variants
15+
Studies
Frequently Asked Questions
What is BPC-157 used for?
BPC-157 is primarily used for tissue repair — tendons, ligaments, gut lining, and muscle. It's the most popular peptide for injury recovery, post-surgical healing, and gut conditions like ulcers and IBD. It works through nitric oxide signaling, angiogenesis, and collagen stimulation.
Does genetics affect BPC-157 response?
Yes. Your NOS3 gene variants affect the nitric oxide pathway BPC-157 activates. CYP3A4 metabolizer status determines clearance speed and dosing considerations. COL1A1 variants influence collagen synthesis response. A genetic peptide report identifies these factors before you start.
Is BPC-157 legal?
As of February 2026, BPC-157 is being reclassified to Category 1 by the FDA, restoring compounding pharmacy access in the US. In the EU, it is available as a research compound. Regulatory status varies by country.
Learn More About BPC-157
Your next move
Two ways forward with BPC-157.
Not sure it's for you?
Will BPC-157 work for your genes — and at what dose?
Your report scores BPC-157 against your receptor, CYP and pathway variants — likely responder, non-responder, and a sensible starting dose — in minutes.
Analyze my DNA — $99Already decided?
Get BPC-157 from Swiss Chems.
A US research-chemical supplier with third-party Certificates of Analysis. Sold for research use only — check your local laws before ordering.
Buy at Swiss Chems →