Semaglutide

What people use Semaglutide for

Reported uses, roughly in order of how often they are the reason someone goes looking. Whether it works for any of them is a separate question, answered under each one.

Weight loss

Around 15% of body weight over 68 weeks, sustained to two years in the longer trial.

Type 2 diabetes

Its first approved use, sold as Ozempic.

Heart attack and stroke prevention

The result that sets it apart: a 20% reduction in serious cardiovascular events in people with heart disease and obesity but no diabetes.

Kidney disease

Tested in people with obesity and chronic kidney disease without diabetes.

Mechanism of Action

How Semaglutide works

Semaglutide dosage calculator

Opens at 0.25 mg, from the doses reported for Semaglutide. Change any box to match your own vial. It works out where to pull the plunger to.

Full reconstitution chart and worked examples.

Semaglutide side effects: what people reported

The best-documented side-effect profile of any peptide here, because millions of people take it. Overwhelmingly digestive, and overwhelmingly during the step-up.

Dose matters. Every dose increase tends to bring a few rough days. People who rush the ramp are the ones who quit.

Source: STEP and SUSTAIN trial programmes, plus years of prescribing data. This is a summary of published findings, not a complete safety profile and not medical advice. Semaglutide should only be considered with a qualified clinician who knows your history.

The dots after each gene are where your own result goes. Your report fills them in with the two letters you carry at that position.

Commonly combined with

What Semaglutide is most often paired with, and why:

BPC-157

GI Protection StackModerate Evidence

Body Protection Compound 157

BPC-157 is the peptide people reach for when something will not heal. Tendons, ligaments, a gut that has been irritated by painkillers, an injury that has stalled. It is a short chain of amino acids copied from part of a protein your stomach already makes, and the animal research on it is unusually consistent for this category: across a lot of separate rat studies, injured tissue healed faster than it did without it. The gap is that this has largely not been repeated in people, and it is not an approved medicine, so nobody is checking what is in the vial you buy.

3

Gene variants

19+

Studies

AOD-9604

Body Composition StackEmerging Evidence

Advanced Obesity Drug 9604 (hGH Fragment 177-191)

AOD-9604 is a fragment cut out of growth hormone, specifically the piece thought to handle fat burning, with the rest of the molecule left behind. The idea was elegant: get the fat-loss effect without the blood-sugar and growth effects of the whole hormone. It is also one of the very few peptides in this space that was put through a proper randomised human trial, which is the part vendors do not mention, because it did not beat the placebo. Development stopped there.

4

Gene variants

15+

Studies

5-Amino-1MQ (Metabolic Stack)

Sourcing & access

Where to buy Semaglutide

Semaglutide is available through licensed telehealth and retail providers. We rank them by price, reviews and a credibility score — so you can find the cheapest source that's actually legitimate.

• Buy only from licensed providers that publish recent third-party purity tests (COAs).
• Compare the total cost — consultation, the compound, and shipping — not just the sticker price.
• Confirm the provider ships to your country and requires a genuine medical intake.

Semaglutide

The appetite regulator

16 clinics

Compare providers→

Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.

Worth knowing before you consider Semaglutide

Interactions and situations where there is a specific reason to be careful. Where the honest answer is that nobody has studied something, it says so and says what that leaves open.

Gut effects are common and are why most people stop

Nausea, diarrhoea, constipation and vomiting are the most frequently reported problems, mostly mild to moderate and worst while the dose is being increased. In the two-year trial, 82% on semaglutide reported a gut side effect at some point, against 54% on placebo.

Compounded semaglutide is not the trialled drug

Every number here comes from the manufacturer's product. Compounded versions sold through telehealth have not been through these trials, and some use a different salt form that was never studied at all.

Weight returns after stopping

The trial that withdrew treatment saw weight regained. It is being studied as an ongoing treatment rather than a course you finish, and that has real cost implications worth knowing before starting.

Frequently Asked Questions