PT-141 - We love peptides! We love better sex! | Sexual Wellness Podcast
A clinic-run podcast episode in which two providers explain PT-141 as they use it for sexual desire and orgasm strength, covering timing, nausea, and why they will not give doses.
With Debra Durst, Faraday Golombieski (nurse practitioner)
Key moments
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- 0:00Introducing the hosts and topicDurst welcomes listeners and introduces co-host Golombieski, a nurse practitioner at the clinic, before turning to PT-141.
- 1:33Link to melanotan IIThe hosts say PT-141 grew out of melanotan II, which affects tanning, appetite and sex drive. They say the sex drive effect led researchers to focus on specific brain receptors.
- 2:35Receptor binding explainedThey describe melanotan II as binding many melanocortin receptors, while PT-141 binds more selectively. They say it gives much less tanning.
- 3:37Forms and timingThe hosts say it is usually an injection or nasal spray taken about an hour ahead. They say onset ranges from 30 minutes to five or six hours.
- 4:39Brain pathway versus blood flowThey contrast PT-141 with Viagra and Cialis, saying those work on blood flow while PT-141 works on central nervous system receptors. They say this is why injections or nasal sprays suit it better than oral forms.
- 6:42Nausea and other side effectsThey say nausea is dose dependent and most likely with a high first dose, and mention anti-nausea options. They also describe mild flushing.
- 8:15Low desire and formulationsThey discuss low libido in men and women and say an approved formulation now exists. They say a compounded vial can last longer than a four-dose version.
- 9:16Couples and combined plansThey say couples use it together and that their clinic pairs it with other sexual wellness treatments while patients wait for other approaches to take effect.
- 10:18Blood pressure monitoringGolombieski and Durst say PT-141 could raise blood pressure, mainly a concern with uncontrolled blood pressure, and that they monitor patients.
- 11:19Why no dosing is givenThey explain reconstitution, say pharmacies can differ tenfold in dosing, and tell viewers to use a prescriber and not to buy online.
What the video says
This episode of a sexual wellness podcast is hosted by Debra Durst, with nurse practitioner Faraday Golombieski as co-host. Both work at a clinic, and the whole 14-minute conversation is about PT-141. They describe it as a peptide they prescribe and like, so it is a clinician's enthusiastic account, not a neutral review.
The pair start with where PT-141 came from. They say it was identified through melanotan II, which they describe as a non-specific binder of melanocortin receptors that raises tanning, lowers appetite and raises sex drive. According to the hosts, PT-141 binds more specifically to receptors including the one tied to sexual function, so it brings far less pigment change. They contrast it with PDE5 inhibitors such as Viagra and Cialis, which they say act on blood flow, while PT-141 acts on receptors in the brain and central nervous system.
On practical use, they say it is usually prescribed as a subcutaneous injection or a nasal spray, and that they expect it to be taken about an hour before sexual activity. They stress that onset varies, from about 30 minutes to five or six hours, so patients have a learning curve. They list nausea as the main side effect, which they say depends on dose and is worst with a higher first dose. They also mention mild flushing and a possible rise in blood pressure, which they monitor. They say patients and couples use it for desire, orgasm strength and erections, sometimes alongside other sexual wellness treatments.
In the closing section the hosts decline to give dosing. They say compounded vials differ between pharmacies, with a tenfold dosing difference depending on the reconstitution volume. They warn against buying peptides online and say patients should be prescribed and medically monitored. The talk is anecdotal and clinic-based, with no studies cited.
On each compound
PT-1411:33
The hosts describe PT-141 as a peptide they prescribe for sexual desire, orgasm strength and erections, acting on brain receptors. They say timing, nausea and dose finding are the main practical issues, and they decline to give doses.
See how your DNA reads PT-141Melanotan II1:33
According to the hosts, melanotan II binds melanocortin receptors broadly, giving tanning, reduced appetite and increased sex drive. They present it as the origin of PT-141, which they say is more selective and causes less pigment change.
See how your DNA reads Melanotan IIWhat this video doesn’t settle
- The video cites no studies, trial data or numbers on effectiveness, so every benefit described is the hosts' clinic experience.
- The hosts run a clinic that prescribes PT-141, and the tone is promotional, so the episode gives no independent view of risks.
- No dose, frequency or reconstitution volume is given, so the video does not say what amount people actually use.
Questions this video answers
How is PT-141 different from Viagra or Cialis according to this video?
The hosts say Viagra and Cialis are PDE5 inhibitors that work on blood flow. They say PT-141 works on receptors in the brain and central nervous system, which they call a neurologic pathway.
How long before sex do the hosts say PT-141 is taken?
They say a typical plan is an injection about an hour before activity. They add that onset could be around 30 minutes or as long as five or six hours, so patients must find their own timing.
What side effects of PT-141 do the hosts mention?
Durst says nausea is the main one and is dose dependent, worst with a higher first dose. Both mention mild flushing, and Durst says blood pressure could rise, mostly a concern when it is already uncontrolled.
How is PT-141 related to melanotan II?
The hosts say PT-141 came out of melanotan II research, which showed that targeting certain brain receptors raised sexual desire. They say PT-141 is more selective, so it gives much less tanning.
Do the hosts give a PT-141 dose?
No. They say dosing depends on the vial strength, the reconstitution volume and the provider. They say pharmacies they use differ tenfold in dosing and advise against buying online.
Video by Dr. Debra Durst, The SexMD on YouTube, embedded as published. The summary is written by PeptidesDNA from the video; every claim in it is the speaker’s. Not affiliated with or endorsed by the creator. Not medical advice.
