TB-500
Thymosin Beta-4 (Fragment)
The systemic healer
A 43-amino-acid peptide identical to the active region of Thymosin Beta-4, the most abundant actin-binding protein in the body. TB-500 promotes cell migration, blood vessel formation, and tissue repair systemically — reaching injuries that localized treatments miss.
Key Benefits
Systemic tissue repair reaching all injury sites simultaneously
Reduced inflammation and accelerated wound healing
Improved flexibility and reduced adhesion formation
Cardiac tissue protection and repair after injury
Hair regrowth via follicle stem cell mobilization
Mechanism of Action
How TB-500 works
TB-500 drives systemic healing through actin regulation and cell mobilization:
- Actin sequestration and polymerization — binds G-actin monomers and promotes their assembly into F-actin filaments, enabling cells to migrate toward injury sites. This is the core mechanism behind TB-500's systemic reach
- Cell migration and differentiation — upregulates stem and progenitor cell migration to damaged tissue. Promotes keratinocyte and endothelial cell movement for wound closure and vessel formation
- Anti-inflammatory modulation — reduces pro-inflammatory cytokines (IL-1beta, TNF-alpha) at injury sites while preserving beneficial acute inflammation needed for initial healing
- Extracellular matrix remodeling — modulates matrix metalloproteinase (MMP) activity to balance tissue breakdown and rebuilding, preventing excessive scar formation
Your Genetics & TB-500
Genetic variants that affect your response
These SNPs determine how effectively TB-500 works for you specifically. A genetic peptide report identifies your variants before you start.
The 5A/6A promoter polymorphism affects MMP3 expression levels. The 5A allele increases matrix breakdown speed — TB-500's MMP modulation may be more critical for 5A carriers to prevent excessive tissue degradation.
Fibronectin is essential for cell migration and wound healing scaffolding. Variants affecting FN1 expression alter the extracellular matrix environment that TB-500 works within, potentially changing migration efficiency.
Determines peptide clearance rate. Poor metabolizers maintain higher TB-500 levels for longer, potentially requiring dose adjustment. Ultra-rapid metabolizers may need higher or more frequent dosing.
Affects baseline VEGF-A production, which drives new blood vessel formation. TB-500 promotes angiogenesis — carriers with lower baseline VEGF may see proportionally greater benefit from this pathway.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
50+
Published studies
Animal studies and in vitro data with promising but limited clinical validation
Common Stacks
TB-500 is commonly combined with:
Frequently Asked Questions
What is TB-500 used for?
TB-500 is used for systemic tissue repair — it travels through the bloodstream to reach injuries throughout the body, unlike localized treatments. It's popular for tendon and ligament injuries, post-surgical recovery, cardiac repair, and chronic inflammatory conditions. It works by promoting cell migration and actin dynamics.
How is TB-500 different from BPC-157?
BPC-157 works locally through nitric oxide and angiogenesis, best for targeted injuries (tendons, gut). TB-500 works systemically through actin regulation, reaching all injury sites simultaneously. Together they form the 'Wolverine Stack' — localized precision plus systemic reach for comprehensive healing.
Does genetics affect TB-500 response?
Yes. MMP3 variants affect your tissue remodeling speed, which TB-500 modulates. FN1 variants influence the cell migration scaffold TB-500 depends on. CYP3A4 metabolizer status determines clearance and dosing considerations. A genetic peptide report identifies these factors before starting a protocol.
Learn More About TB-500
Personalize your protocol
Does TB-500 match your DNA?
Upload your existing genetic data or order a kit. Your report scores TB-500 against your unique genetic profile — CYP metabolism, receptor variants, pathway markers — in minutes.