TB-500
Thymosin Beta-4 (Fragment)
The systemic healer
A 43-amino-acid peptide identical to the active region of Thymosin Beta-4, the most abundant actin-binding protein in the body. TB-500 promotes cell migration, blood vessel formation, and tissue repair systemically — reaching injuries that localized treatments miss.
- Route
- Subcutaneous
- Typical dose
- 2–5 mg 2x/week
- Availability
- Research-only
Key Benefits
Systemic tissue repair reaching all injury sites simultaneously
Reduced inflammation and accelerated wound healing
Improved flexibility and reduced adhesion formation
Cardiac tissue protection and repair after injury
Hair regrowth via follicle stem cell mobilization
Mechanism of Action
How TB-500 works
TB-500 drives systemic healing through actin regulation and cell mobilization:
- Actin sequestration and polymerization — binds G-actin monomers and promotes their assembly into F-actin filaments, enabling cells to migrate toward injury sites. This is the core mechanism behind TB-500's systemic reach
- Cell migration and differentiation — upregulates stem and progenitor cell migration to damaged tissue. Promotes keratinocyte and endothelial cell movement for wound closure and vessel formation
- Anti-inflammatory modulation — reduces pro-inflammatory cytokines (IL-1beta, TNF-alpha) at injury sites while preserving beneficial acute inflammation needed for initial healing
- Extracellular matrix remodeling — modulates matrix metalloproteinase (MMP) activity to balance tissue breakdown and rebuilding, preventing excessive scar formation
Your Genetics & TB-500
Genetic variants that affect your response
These SNPs determine how effectively TB-500 works for you specifically. A genetic peptide report identifies your variants before you start.
The 5A/6A promoter polymorphism affects MMP3 expression levels. The 5A allele increases matrix breakdown speed — TB-500's MMP modulation may be more critical for 5A carriers to prevent excessive tissue degradation.
Fibronectin is essential for cell migration and wound healing scaffolding. Variants affecting FN1 expression alter the extracellular matrix environment that TB-500 works within, potentially changing migration efficiency.
Determines peptide clearance rate. Poor metabolizers maintain higher TB-500 levels for longer, potentially requiring dose adjustment. Ultra-rapid metabolizers may need higher or more frequent dosing.
Affects baseline VEGF-A production, which drives new blood vessel formation. TB-500 promotes angiogenesis — carriers with lower baseline VEGF may see proportionally greater benefit from this pathway.
Which variants do you carry?
Upload your DNA data or order a kit to find out.
Evidence & Research
50+
Published studies
Animal studies and in vitro data with promising but limited clinical validation
Sourcing & access
Where to buy TB-500
TB-500 is sold as a research compound, not a licensed medicine, so quality and legal status vary widely by country and vendor. If you're sourcing it, treat independent purity testing as non-negotiable.
- Insist on a recent third-party Certificate of Analysis (COA) for the exact batch — labs like Janoshik verify purity and identity.
- Check the legal status where you live before ordering — it differs from country to country.
- Reconstitute correctly with bacteriostatic water and start at a conservative dose.
Swiss Chems is a US research-chemical supplier that publishes third-party Certificates of Analysis. Sold for research use only — check your local laws.
Before you buy: see whether your DNA actually responds to TB-500, and at what dose. Analyze my DNA — $99 →
Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.
Common Stacks
TB-500 is commonly combined with:
BPC-157
Wolverine StackModerate EvidenceBody Protection Compound 157
A 15-amino-acid peptide derived from human gastric juice. The most-researched peptide for tissue repair, gut healing, and injury recovery. Works through nitric oxide signaling, angiogenesis, and collagen stimulation.
4
Gene variants
100+
Studies
GHK-Cu
Full Regeneration StackModerate EvidenceGlycyl-L-Histidyl-L-Lysine Copper Complex
A naturally occurring copper-binding tripeptide that declines with age. GHK-Cu resets gene expression toward a younger pattern, stimulates collagen synthesis, activates antioxidant defenses, and promotes tissue remodeling across skin, bone, and connective tissue.
CJC-1295
Recovery StackModerate EvidenceCJC-1295 (Modified GRF 1-29)
A 29-amino-acid growth hormone releasing hormone (GHRH) analog with enhanced stability. CJC-1295 extends the duration of natural GH pulses without disrupting pulsatile release patterns, providing sustained elevation of growth hormone and IGF-1 for recovery, body composition, and anti-aging.
4
Gene variants
30+
Studies
Frequently Asked Questions
What is TB-500 used for?
TB-500 is used for systemic tissue repair — it travels through the bloodstream to reach injuries throughout the body, unlike localized treatments. It's popular for tendon and ligament injuries, post-surgical recovery, cardiac repair, and chronic inflammatory conditions. It works by promoting cell migration and actin dynamics.
How is TB-500 different from BPC-157?
BPC-157 works locally through nitric oxide and angiogenesis, best for targeted injuries (tendons, gut). TB-500 works systemically through actin regulation, reaching all injury sites simultaneously. Together they form the 'Wolverine Stack' — localized precision plus systemic reach for comprehensive healing.
Does genetics affect TB-500 response?
Yes. MMP3 variants affect your tissue remodeling speed, which TB-500 modulates. FN1 variants influence the cell migration scaffold TB-500 depends on. CYP3A4 metabolizer status determines clearance and dosing considerations. A genetic peptide report identifies these factors before starting a protocol.
Learn More About TB-500
Your next move
Two ways forward with TB-500.
Not sure it's for you?
Will TB-500 work for your genes — and at what dose?
Your report scores TB-500 against your receptor, CYP and pathway variants — likely responder, non-responder, and a sensible starting dose — in minutes.
Analyze my DNA — $99Already decided?
Get TB-500 from Swiss Chems.
A US research-chemical supplier with third-party Certificates of Analysis. Sold for research use only — check your local laws before ordering.
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