Tirzepatide

What people use Tirzepatide for

Reported uses, roughly in order of how often they are the reason someone goes looking. Whether it works for any of them is a separate question, answered under each one.

Weight loss

The use with the most evidence. Around 20% of body weight over 72 weeks at the top dose.

Type 2 diabetes

Its original approved use, sold as Mounjaro, where it lowers blood sugar and weight together.

Obstructive sleep apnoea

Approved for this after two trials showed large falls in breathing interruptions during sleep.

Preventing diabetes

In people with obesity and prediabetes, far fewer went on to develop diabetes over three years.

Mechanism of Action

How Tirzepatide works

Tirzepatide dosage calculator

Opens at 2.5 mg, from the doses reported for Tirzepatide. Change any box to match your own vial. It works out where to pull the plunger to.

Full reconstitution chart and worked examples.

Tirzepatide side effects: what people reported

Almost everything people report is digestive, and almost all of it happens while the dose is going up rather than once you settle. Most people who stop, stop in the first two months.

Dose matters. Each step up tends to bring a rough few days, then it settles. Going up slower is the single most effective thing you can do about it.

Source: SURMOUNT and SURPASS trial programmes, plus widespread prescribing experience. This is a summary of published findings, not a complete safety profile and not medical advice. Tirzepatide should only be considered with a qualified clinician who knows your history.

The dots after each gene are where your own result goes. Your report fills them in with the two letters you carry at that position.

Commonly combined with

What Tirzepatide is most often paired with, and why:

BPC-157

GI Protection StackModerate Evidence

Body Protection Compound 157

BPC-157 is the peptide people reach for when something will not heal. Tendons, ligaments, a gut that has been irritated by painkillers, an injury that has stalled. It is a short chain of amino acids copied from part of a protein your stomach already makes, and the animal research on it is unusually consistent for this category: across a lot of separate rat studies, injured tissue healed faster than it did without it. The gap is that this has largely not been repeated in people, and it is not an approved medicine, so nobody is checking what is in the vial you buy.

3

Gene variants

19+

Studies

AOD-9604

Body Composition StackEmerging Evidence

Advanced Obesity Drug 9604 (hGH Fragment 177-191)

AOD-9604 is a fragment cut out of growth hormone, specifically the piece thought to handle fat burning, with the rest of the molecule left behind. The idea was elegant: get the fat-loss effect without the blood-sugar and growth effects of the whole hormone. It is also one of the very few peptides in this space that was put through a proper randomised human trial, which is the part vendors do not mention, because it did not beat the placebo. Development stopped there.

4

Gene variants

15+

Studies

Tesamorelin

Visceral Fat StackStrong Evidence

Tesamorelin (GHRH Analog)

A stabilized growth-hormone-releasing-hormone (GHRH) analog and the only GH-axis peptide with an FDA approval (Egrifta, for visceral fat in HIV-associated lipodystrophy). It stimulates your own pulsatile GH release, which drives IGF-1 and preferential breakdown of visceral (deep belly) fat — backed by real randomized trial data on VAT reduction. Off-label use for visceral fat is common. WADA-banned in sport.

3

Gene variants

40+

Studies

Sourcing & access

Where to buy Tirzepatide

Tirzepatide is available through licensed telehealth and retail providers. We rank them by price, reviews and a credibility score — so you can find the cheapest source that's actually legitimate.

• Buy only from licensed providers that publish recent third-party purity tests (COAs).
• Compare the total cost — consultation, the compound, and shipping — not just the sticker price.
• Confirm the provider ships to your country and requires a genuine medical intake.

Tirzepatide

The dual incretin

16 clinics

Compare providers→

Educational information only, not medical advice. Some outbound links are affiliate links (disclosed, at no extra cost to you). Most peptides are not FDA-approved — consult a qualified professional and check your local laws before purchasing.

Worth knowing before you consider Tirzepatide

Interactions and situations where there is a specific reason to be careful. Where the honest answer is that nobody has studied something, it says so and says what that leaves open.

Nausea and other gut effects are the usual reason people stop

Across the trials the most common problems were gastrointestinal: nausea, diarrhoea, constipation and vomiting. Most were mild to moderate and clustered in the first weeks while the dose was being stepped up, which is exactly why the dose is escalated slowly rather than started high.

Compounded versions are not the trialled drug

Every result on this page comes from the manufacturer's product. Compounded tirzepatide sold through telehealth is a different preparation that has not been through those trials, and the FDA has warned about dosing errors when people measure it themselves.

Weight comes back when you stop

In the trial that withdrew treatment, weight was regained. That is a finding about the drug rather than about willpower: it is being studied as a long-term treatment, and stopping returns the appetite signalling to where it started.

Frequently Asked Questions