The Harsh Truth About Peptides - Andrew Huberman
A short clip in which Andrew Huberman describes his own experience with BPC-157, pinealon and growth hormone secretagogues, then moves on to psychedelic therapy.
With Andrew Huberman, Chris Williamson
Key moments
Tap a moment to play the video from there.
- 0:00Protocols he cannot fully proveWilliamson asks about protocols Huberman believes in without scientific proof. Huberman says these will be things that are not in his book.
- 0:30Shoulder pain and BPC-157 injectionsHuberman describes shoulder pain after returning to heavy presses. He says two small injections of about 100 or 200 micrograms made it disappear, and that placebo is possible.
- 1:30The preclinical dataHe says the BPC-157 data come from preclinical studies. He says the supporting data for it are preclinical.
- 2:30Pinealon and REM sleepHuberman says he takes about a tenth of a unit every third or fourth night. He reports two and a half to three hours of REM in six to seven hours of sleep.
- 4:01Growth hormone secretagogues disagree with himHe names tesamorelin, ipamorelin and CJC and says he is not a fan. He reports reduced REM sleep and a higher PSA.
- 4:31Tumor risk and the MRIHe admits he might grow a tumor from injecting BPC-157. He says his whole-body MRI indicates he has not.
- 5:01Psychedelic therapy in clinical settingsThe talk moves to MDMA and psilocybin therapy for PTSD and depression. Huberman says he tried a combination in a clinical setting.
- 7:01What outcome do you want?Huberman compares asking whether to use peptides with asking whether to invest, and says the useful question is what result the person wants.
- 8:00DMT worries and a kidnapping storyHe says he is more wary of DMT than ibogaine. The clip then drifts into jokes and a story about waking up in Utah.
What the video says
This is a short clip from Chris Williamson's podcast. Andrew Huberman is asked which protocols he believes in but cannot scientifically prove. Peptides take up roughly the first five minutes. The rest covers psychedelic therapy, ibogaine and DMT, a personal anecdote, and a sponsor read.
Huberman's main peptide story is about BPC-157. He says he developed shoulder pain a couple of months after returning to heavy pressing movements, and that rotation exercises and lighter loads did not help. He then gave himself two injections of roughly 100 or 200 micrograms and says the pain disappeared. He allows that it could be placebo, since he knew what he was injecting. He also says the supporting data are from preclinical studies. He finds that hard to put down to placebo, though he notes the owners may be changing other things too.
He next describes pinealon, which he says comes from brain tissue rather than the pineal gland. He reports taking about a tenth of a unit every third or fourth night and getting two and a half to three hours of REM sleep in six to seven hours, with the effect continuing when he cut back to once a week or every ten days. His one downside is some difficulty concentrating the next day. Of the growth hormone secretagogues, he names tesamorelin, ipamorelin and CJC and says he is not a fan. He says they reduced his REM sleep and raised his PSA.
Huberman says he is curious about low-dose growth hormone but, at 51, feels good without it. He concedes that he could be growing a tumor from BPC-157 and says his whole-body MRI suggests otherwise. The clip then turns to MDMA and psilocybin therapy, ibogaine and DMT, and his remark that people asking about peptides should first say what outcome they want.
On each compound
BPC-1570:30
Huberman says two injections of about 100 or 200 micrograms near a painful shoulder made the pain disappear, though he allows it may be placebo. He says the data on it are from preclinical studies. He also says he could in theory grow a tumor from it but that his whole-body MRI says otherwise.
See how your DNA reads BPC-157Ipamorelin4:01
Huberman says he is not a fan of growth hormone secretagogues such as ipamorelin. He says they always reduced his REM sleep and raised his PSA.
See how your DNA reads IpamorelinCJC-12954:01
Huberman lists CJC among the growth hormone secretagogues he does not like. He says they reduced his REM sleep and raised his PSA.
See how your DNA reads CJC-1295Tesamorelin4:01
Huberman names tesamorelin among the secretagogues that did not suit him. He says it was part of a group that affected his REM sleep and PSA.
See how your DNA reads Tesamorelin“Of course, I might grow a tumor myself by injecting BPC.”
What this video doesn’t settle
- Everything about BPC-157, pinealon and the secretagogues is one person's experience, with no control group or blinding.
- Huberman says the BPC-157 data are preclinical, so the clip does not establish whether it does anything in people or what a safe dose is.
Questions this video answers
What does Huberman say about BPC-157 for shoulder pain?
He says two injections of roughly 100 or 200 micrograms near his sore shoulder were followed by the pain disappearing. He says it could be placebo because he knew what he was taking.
Does Huberman say BPC-157 has human evidence?
He says the data he knows of are from preclinical studies. He calls them impressive but relies mostly on personal experience and reports from other people.
Which growth hormone secretagogues does Huberman avoid?
He names tesamorelin, ipamorelin and CJC and says he is not a fan. He says they reduced his REM sleep and raised his PSA.
What does Huberman say about pinealon and sleep?
He says he took about a tenth of a unit every third or fourth night and got two and a half to three hours of REM in six to seven hours of sleep. He says the effect continued when he dosed less often, and his only downside was harder concentration the next day.
Is Huberman worried about tumor risk from peptides?
He says he cannot rule out growing a tumor from injecting BPC-157. He adds that his whole-body MRI says he has not.
Video by Chris Williamson on YouTube, embedded as published. The summary is written by PeptidesDNA from the video; every claim in it is the speaker’s. Not affiliated with or endorsed by the creator. Not medical advice.
