MAXIMIZE Growth Hormone With Ipamorelin & Tesamorelin (Cheat-Sheet) MK-677, GHRP-6, CJC-1295 & More!
A creator's cheat-sheet on growth hormone secretagogues, covering doses, popular stacks, lifestyle add-ons and inhibitors, ending with why he prefers exogenous growth hormone.
Key moments
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- 0:20How growth hormone release worksHe explains pulsatile secretion, the sleep peak, and how exercise, fasting and cortisol are said to affect it. He also introduces growth hormone releasing hormone, ghrelin and somatostatin.
- 5:57Secretagogues sorted by receptorHe lists growth hormone releasing hormone agonists such as CJC-1295 and tesamorelin, with the dose ranges and frequencies he gives for each.
- 7:10Ghrelin receptor agonists and oral optionsHe covers GHRP-2, GHRP-6, hexarelin, ipamorelin and oral MK-677, again with doses. He notes that only a few options are orally bioavailable.
- 8:13Popular stacks and their appealHe says many people favor weekly CJC-1295 with DAC plus nightly MK-677 for convenience. He says others prefer tesamorelin with ipamorelin injections.
- 9:14Add-ons that may raise outputHe runs through training, amino acids, melatonin, GABA, creatine, fasting habits and arginine-based efforts to blunt somatostatin at bedtime.
- 11:18DPP-4 inhibitors and other ideasHe mentions clonidine, nicotine and DPP-4 inhibitors as possible helpers. He cautions that clear evidence is lacking and that these inhibitors also affect many other growth factors.
- 13:21What to avoidHe lists somatostatin, high blood glucose, free fatty acids, benzodiazepines, baclofen, glucocorticoids and insulin as things that blunt secretion.
- 15:41Cost versus results argumentHe argues that exogenous growth hormone may give more result per dollar than a pile of supplements and secretagogues, especially for older users.
- 16:54Age decline and his own resultsHe cites a review on falling secretion with age, then says his own levels are higher on exogenous growth hormone than on any secretagogue protocol. He suggests viewers test their own bloodwork.
What the video says
VigorousSteve, a creator speaking from his own experience, presents a cheat-sheet for people who already use or are considering growth hormone secretagogues and want to push output further. He opens with the biology as he understands it: growth hormone is released in pulses, with the largest during early sleep, and he says the size of the peaks falls with age. He describes growth hormone releasing hormone and ghrelin as the drivers, and somatostatin and circulating IGF-1 as the brakes.
He then sorts the compounds by receptor. Among growth hormone releasing hormone agonists he names CJC-1295 with and without DAC and tesamorelin, and among ghrelin receptor agonists he names GHRP-2, GHRP-6, hexarelin and ipamorelin, plus oral MK-677. He gives dose ranges and injection frequencies for each. He says the stacks he sees most often are weekly CJC-1295 with DAC plus bedtime MK-677, or tesamorelin with ipamorelin injected one to three times a day.
The middle of the video lists other things he says can raise or protect growth hormone secretion: sleep, hard aerobic and resistance training, fasting, melatonin, GABA, creatine, and amino acids such as arginine, ornithine and lysine to blunt somatostatin. He also mentions DPP-4 inhibitors and says the evidence for them is unclear. He then lists things he says to avoid, including high blood glucose, high free fatty acids, benzodiazepines, baclofen, glucocorticoids and insulin.
He closes on cost and results. He argues that stacking secretagogues with all these measures may deliver little for older users, cites a review on declining secretion with age, and says that at his age he uses exogenous growth hormone and sees higher growth hormone and IGF-1 levels than on any secretagogue protocol he tried. He stresses this is his own anecdote and suggests checking blood work before and after.
On each compound
CJC-12956:09
VigorousSteve lists CJC-1295 as a growth hormone releasing hormone agonist, giving 150 micrograms to 300 micrograms up to three times daily, or 1 milligram to 2 milligram once weekly with DAC. He says CJC-1295 with DAC plus oral MK-677 is among the most popular combinations.
See how your DNA reads CJC-1295Tesamorelin6:40
He gives tesamorelin as 1 milligram to 2 milligram subcutaneously up to three times daily. He says people comfortable with injections often pair it with ipamorelin.
See how your DNA reads TesamorelinIpamorelin7:10
He lists ipamorelin as a ghrelin receptor agonist at 150 microgram to 300 microgram subcutaneously up to three times daily. He says a tesamorelin and ipamorelin pairing is favored by people who accept frequent injections.
See how your DNA reads IpamorelinGHRP-27:10
He names GHRP-2 as a ghrelin receptor agonist at 150 micrograms to 300 microgram subcutaneously up to three times daily.
See how your DNA reads GHRP-2GHRP-67:10
He gives GHRP-6 as 100 microgr to 200 microgram subcutaneously up to three times daily. He notes that ghrelin receptor agonism increases hunger, which he calls a known side effect.
See how your DNA reads GHRP-6Hexarelin7:10
He lists hexarelin as a ghrelin receptor agonist at 100 micrograms to 150 microgr subcutaneously up to three times daily.
See how your DNA reads HexarelinWhat this video doesn’t settle
- His comparison of secretagogues with exogenous growth hormone rests on his own anecdote, with no control group or measured data shown.
- He says himself that evidence is thin or missing for several suggestions, such as DPP-4 inhibitors, GLP-1 effects and the effect of DHT derivatives.
- The doses and frequencies are his stated ranges, with no source given and no discussion of safety, side effects beyond hunger, or individual variation.
Questions this video answers
What growth hormone secretagogue combinations does VigorousSteve say are most popular?
He says the most popular stack appears to be CJC-1295 with DAC once a week plus oral MK-677 before bed. He adds that people who accept more injections tend to choose tesamorelin with ipamorelin, injected once to three times a day.
What does VigorousSteve say blunts growth hormone secretion?
He names somatostatin, rising IGF-1 feedback, high blood glucose, high free fatty acids, benzodiazepines, baclofen, glucocorticoids and insulin. He says some of this, such as the IGF-1 feedback, cannot be worked around.
What lifestyle steps does the video say may raise growth hormone?
He cites sleeping on a circadian schedule, vigorous exercise above the lactate threshold for at least 10 minutes, and fasting, with longer fasts having a stronger effect. He also lists melatonin, GABA, creatine and arginine with ornithine and lysine.
Does VigorousSteve recommend secretagogues or exogenous growth hormone?
He says that at his age he expects little from secretagogues and uses exogenous growth hormone instead. He says his growth hormone and IGF-1 levels are far higher that way, and stresses this is only his own experience.
Video by VigorousSteve on YouTube, embedded as published. The summary is written by PeptidesDNA from the video; every claim in it is the speaker’s. Not affiliated with or endorsed by the creator. Not medical advice.
