TIER LIST PEPTIDE EDITION
A six-minute personal tier list in which a cycling and lifting YouTuber ranks IGF-1, semaglutide, tesofensine, BPC-157, TB-500, glutathione and tesamorelin by how useful he finds each one.
Key moments
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- 0:00How the tiers are definedDoucette explains his four tiers, from tier three (maybe useful) up to S tier (everyone should use it), and stresses that the list is only his opinion.
- 0:34IGF-1 lands in tier threeHe says IGF-1 can help build muscle, but he has used it for years and no longer wants to inject around every workout.
- 1:12Semaglutide and muscle lossHe ranks semaglutide in tier three, citing appetite suppression and potential muscle loss. He says it could matter a lot for someone with type 2 diabetes who is far overweight.
- 1:50Tesofensine over semaglutideHe puts tesofensine in tier two. He says it has not been shown to cost muscle, and he would favour it for someone wary of nausea.
- 2:51His cookbook tops the listHe ranks his own cookbook above the drugs, saying a calorie deficit from its meals keeps him lean and full.
- 3:12BPC-157 as injury supportHe explains why BPC-157 is S tier for him: years of powerlifting, surgeries and a recurring shoulder problem.
- 4:25Glutathione in tier oneHe describes glutathione as a powerful antioxidant and says he hopes it supports his immune system and liver.
- 5:11Tesamorelin and final thoughtsHe puts tesamorelin in tier two, mentions its FDA approval, and lists fat loss, IGF-1 and sleep as possible benefits before asking viewers for feedback.
What the video says
Greg Doucette presents a tier list of peptides that he describes as purely his own opinion. He defines the tiers himself. Tier three means maybe useful, tier two means probably beneficial, tier one means absolutely useful, and S tier means everyone should be using it. He says up front that the rankings reflect his own situation, which he describes as a 48-year-old former powerlifter who now races bicycles and lifts regularly.
On the weight and muscle side, Doucette puts IGF-1 and semaglutide in tier three. He says he has used IGF-1 for years but no longer wants to inject it around every workout. He says semaglutide sharply reduces appetite but has been shown to risk muscle loss, which he wants to avoid. He allows that it could make a large difference for someone with type 2 diabetes who is 50 or 100 lb overweight. Tesofensine lands in tier two. He says there is no real evidence it causes muscle loss, that it lowers appetite, and that it may improve mood. He would pick it over semaglutide for someone worried about nausea and muscle loss. His own cookbook gets the top spot over either drug.
The recovery picks rank higher. He places BPC-157 and TB-500 together in S tier as what he calls the Wolverine stack. He says he takes both now, mainly for a nagging shoulder, and that they could help injured athletes recover and return to training. He puts glutathione in tier one, calling it a strong antioxidant and saying it may support the immune system after a year of frequent illness. Tesamorelin goes in tier two. He notes it is FDA approved and says it may help with fat loss, raise IGF-1 by perhaps 20%, and improve sleep and recovery.
The video is a short opinion piece. It gives no doses, protocols or sources, and the speaker says openly that the ranking is personal.
On each compound
IGF-10:34
Doucette ranks IGF-1 in tier three. He says it can help build muscle but he already has enough muscle and does not want to inject it every day.
See how your DNA reads IGF-1Semaglutide1:12
Doucette puts semaglutide in tier three. He says it sharply lowers appetite but has been shown to risk muscle loss, and that it may suit someone with type 2 diabetes who is 50 or 100 lb overweight.
See how your DNA reads SemaglutideBPC-1573:12
Doucette ranks BPC-157 in S tier. He says he has used it mainly for a shoulder injury and thinks it can help people stay injury-free and train harder.
See how your DNA reads BPC-157TB-5003:33
Doucette pairs TB-500 with BPC-157 as the Wolverine stack and says he takes both. He believes TB-500 is now called thymosin beta 4 and says the stack could help recovery for lifters and runners.
See how your DNA reads TB-500Tesamorelin5:11
Doucette ranks tesamorelin in tier two. He says it is FDA approved and may help burn fat, raise IGF-1 by perhaps 20%, and improve sleep and recovery.
See how your DNA reads Tesamorelin“it's literally the Wolverine stack”
What this video doesn’t settle
- The rankings are one cyclist's personal preferences and are not based on trials or cited sources.
- No doses, injection protocols, sourcing or safety data are given for any compound.
- His claims for BPC-157, TB-500 and glutathione rest on his own experience, with no control group.
Questions this video answers
Why does Greg Doucette rank semaglutide in tier three?
He says he does not need to lose weight and wants to avoid muscle loss, which he says semaglutide has been shown to risk. He adds that it could make a big difference for someone with type 2 diabetes who is 50 or 100 lb overweight.
What is the BPC-157 and TB-500 Wolverine stack?
Doucette uses the name for taking BPC-157 and TB-500 together. He says he takes both, mainly for a nagging shoulder, and ranks them in S tier. He says they could help injured people recover and return to training.
Why would someone pick tesofensine over semaglutide, according to this video?
Doucette says tesofensine has not been shown to cause muscle loss, while semaglutide has. He also suggests it for people who fear nausea. He still says it reduces appetite and may improve mood.
What does Doucette say tesamorelin does?
He says it is FDA approved and may help burn fat. He also says it could raise IGF-1 levels by perhaps 20%, improve sleep, and speed recovery between training days.
Video by Greg Doucette on YouTube, embedded as published. The summary is written by PeptidesDNA from the video; every claim in it is the speaker’s. Not affiliated with or endorsed by the creator. Not medical advice.
